He is administered a drug that inhibits bacterial enzyme that catalyzes bacterial DNA synthesis. The drug cited above produced the kinetic data shown below. The mechanism of action of the drug is non-competitive inhibition of enzyme; drug binds to active site. Please explain.

Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
icon
Related questions
Question

A 45 year-old male presents with fever and cough. He is found to have bacterial pneumonia. He is administered a drug that inhibits bacterial enzyme that catalyzes bacterial DNA synthesis. The drug cited above produced the kinetic data shown below. The mechanism of action of the drug is non-competitive inhibition of enzyme; drug binds to active site. Please explain

Enzyme
Enzyme plus Drug
Michaelis constant
5.0 x 10-5
mmol/uL
5.0 x 10-5
mmol/uL
Vmax
1.5 x 10-20
mmol/ul/sec
1.5 x 10-70
mmol/uL/sec
Transcribed Image Text:Enzyme Enzyme plus Drug Michaelis constant 5.0 x 10-5 mmol/uL 5.0 x 10-5 mmol/uL Vmax 1.5 x 10-20 mmol/ul/sec 1.5 x 10-70 mmol/uL/sec
Expert Solution
steps

Step by step

Solved in 3 steps

Blurred answer
Similar questions
Recommended textbooks for you
Biochemistry
Biochemistry
Biochemistry
ISBN:
9781319114671
Author:
Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:
W. H. Freeman
Lehninger Principles of Biochemistry
Lehninger Principles of Biochemistry
Biochemistry
ISBN:
9781464126116
Author:
David L. Nelson, Michael M. Cox
Publisher:
W. H. Freeman
Fundamentals of Biochemistry: Life at the Molecul…
Fundamentals of Biochemistry: Life at the Molecul…
Biochemistry
ISBN:
9781118918401
Author:
Donald Voet, Judith G. Voet, Charlotte W. Pratt
Publisher:
WILEY
Biochemistry
Biochemistry
Biochemistry
ISBN:
9781305961135
Author:
Mary K. Campbell, Shawn O. Farrell, Owen M. McDougal
Publisher:
Cengage Learning
Biochemistry
Biochemistry
Biochemistry
ISBN:
9781305577206
Author:
Reginald H. Garrett, Charles M. Grisham
Publisher:
Cengage Learning
Fundamentals of General, Organic, and Biological …
Fundamentals of General, Organic, and Biological …
Biochemistry
ISBN:
9780134015187
Author:
John E. McMurry, David S. Ballantine, Carl A. Hoeger, Virginia E. Peterson
Publisher:
PEARSON