GWAS and PheWAS experiments both aim to link genotypes and phenotypes, albeit using slightly different approaches. Which approach is likely a better choice to use to determine the genetic basis for an incredibly rare disorder affecting 1 in 10,000,000 people? GWAS is better PheWAS is better Both are always equally as good Neither is a good choice.
Genetic Variation
Genetic variation refers to the variation in the genome sequences between individual organisms of a species. Individual differences or population differences can both be referred to as genetic variations. It is primarily caused by mutation, but other factors such as genetic drift and sexual reproduction also play a major role.
Quantitative Genetics
Quantitative genetics is the part of genetics that deals with the continuous trait, where the expression of various genes influences the phenotypes. Thus genes are expressed together to produce a trait with continuous variability. This is unlike the classical traits or qualitative traits, where each trait is controlled by the expression of a single or very few genes to produce a discontinuous variation.
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