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Galactose 1-phosphate: UDP-glucose uridyltransferase (GALT) is an enzyme important for the catabolism of galactose.  Patients with GALT deficiency present within days of birth with feeding difficulty, fatigue, jaundice and liver problems, and failure to thrive.  In addition, a buildup of galactose and its metabolites are present in the bloodstream.  GALT catalyzes the following reaction in galactose catabolism.  NOTE that GALT is reversible!! Classify this enzyme and explain why you classified it in this way.

Galactose 1-phosphate: UDP-glucose uridyltransferase (GALT) is an enzyme important for the catabolism of galactose.  Patients with GALT deficiency present within days of birth with feeding difficulty, fatigue, jaundice and liver problems, and failure to thrive.  In addition, a buildup of galactose and its metabolites are present in the bloodstream.  GALT catalyzes the following reaction in galactose catabolism.  NOTE that GALT is reversible!! Classify this enzyme and explain why you classified it in this way.

Biochemistry
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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Galactose 1-phosphate: UDP-glucose uridyltransferase (GALT) is an enzyme important for the catabolism of galactose.  Patients with GALT deficiency present within days of birth with feeding difficulty, fatigue, jaundice and liver problems, and failure to thrive.  In addition, a buildup of galactose and its metabolites are present in the bloodstream.  GALT catalyzes the following reaction in galactose catabolism.  NOTE that GALT is reversible!!

Classify this enzyme and explain why you classified it in this way.

 

 

**Galactose Metabolism Pathway** The diagram illustrates an essential reaction in the metabolism of galactose, focusing on the conversion of galactose 1-phosphate into glucose 1-phosphate. 1. **Galactose 1-phosphate**: The structure at the top represents galactose 1-phosphate, which includes a phosphate group attached to the sugar molecule. 2. **UDP-glucose**: This molecule, labeled on the left, is involved in the reaction and is crucial for the conversion process. 3. **Enzyme**: The enzyme UDP-glucose:galactose 1-phosphate uridylyltransferase facilitates the transfer process. It converts galactose 1-phosphate into glucose 1-phosphate by transferring a UDP group. 4. **Product Formation**: - **Glucose 1-phosphate**: The molecule labeled in blue represents the final product, glucose 1-phosphate. This product can enter glycolysis or be stored as glycogen. - **UDP-galactose**: Formed as a byproduct, this molecule contains UDP (uridine diphosphate) linked with galactose. The diagram effectively highlights the molecular transformations and enzyme activities necessary for processing galactose within the body.
Transcribed Image Text:**Galactose Metabolism Pathway** The diagram illustrates an essential reaction in the metabolism of galactose, focusing on the conversion of galactose 1-phosphate into glucose 1-phosphate. 1. **Galactose 1-phosphate**: The structure at the top represents galactose 1-phosphate, which includes a phosphate group attached to the sugar molecule. 2. **UDP-glucose**: This molecule, labeled on the left, is involved in the reaction and is crucial for the conversion process. 3. **Enzyme**: The enzyme UDP-glucose:galactose 1-phosphate uridylyltransferase facilitates the transfer process. It converts galactose 1-phosphate into glucose 1-phosphate by transferring a UDP group. 4. **Product Formation**: - **Glucose 1-phosphate**: The molecule labeled in blue represents the final product, glucose 1-phosphate. This product can enter glycolysis or be stored as glycogen. - **UDP-galactose**: Formed as a byproduct, this molecule contains UDP (uridine diphosphate) linked with galactose. The diagram effectively highlights the molecular transformations and enzyme activities necessary for processing galactose within the body.
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