For the following mechanism, a modified Horner-Wadsworth-Emmons (HWE) reaction was performed. How is this different to a Wittig reaction? What are the main benefits of the HWE reaction? -CO̟EtOAc-co,EtOCH3(i) dil aq. HCI, 70 °CLipase PS,t-BUOCH3, 168 hOHон (S)-2(iї) K-СОз, 168 hOCH3-CO2Et1CO̟EtEto-PEtOОНОАс 3(R/S)-2Figure 2.2: Synthesis of (R/S)-2 and kinetic resolution with lipase PS.

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Answered: For the following mechanism, a modified…

For the following mechanism, a modified Horner-Wadsworth-Emmons (HWE) reaction was performed. How is this different to a Wittig reaction? What are the main benefits of the HWE reaction

Chemistry

10th Edition

ISBN:9781305957404

Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Chapter1: Chemical Foundations

Section: Chapter Questions

Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...

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Question

For the following mechanism, a modified Horner-Wadsworth-Emmons (HWE) reaction was performed. How is this different to a Wittig reaction? What are the main benefits of the HWE reaction?

-CO̟Et
OAc
-co,Et
OCH3
(i) dil aq. HCI, 70 °C
Lipase PS,
t-BUOCH3, 168 h
OH
он (S)-2
(iї) K-СОз, 168 h
OCH3
-CO2Et
1
CO̟Et
Eto-P
EtO
ОН
ОАс 3
(R/S)-2
Figure 2.2: Synthesis of (R/S)-2 and kinetic resolution with lipase PS.

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