For each of the following reactions, predict the major product. NaOH H20 1. NaH 2. О 3. HCI, H20, Д H3C-NO2

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**Transcription and Explanation for Educational Website**

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**Chemical Reactions: Predicting Major Products**

The image presents a series of chemical reactions where the goal is to predict the major product formed in each reaction. Below are the detailed descriptions and conditions for each reaction:

1. **Reaction 1: Aldol Reaction**
   - **Starting Material:** 
     - A ketone with the formula CH₃C(O)CH₃.
   - **Reagents and Conditions:**
     - Sodium hydroxide (NaOH) in aqueous solution (H₂O).
   - **Description:**
     - This is a classic aldol reaction where an enolate ion is formed. The enolate then attacks the carbonyl carbon of another molecule of the ketone leading to the aldol product.

2. **Reaction 2: Claisen Condensation**
   - **Starting Materials:** 
     - A ketone similar to the first reaction, and a cyclic ester (lactone).
   - **Reagents and Conditions:**
     - Step 1: Sodium hydride (NaH).
     - Step 2: Introduction of a carbonyl compound, specifically a cyclic ketone.
     - Step 3: Hydrochloric acid (HCl), water (H₂O), and heat (Δ).
   - **Description:**
     - This is a Claisen condensation involving the deprotonation of the ketone by NaH to form an enolate. The enolate acts as a nucleophile and attacks the carbonyl carbon of the cyclic ester. Finally, hydrolysis under acidic conditions and heat leads to the final product.

3. **Reaction 3: Nitro-Mannich Reaction**
   - **Starting Materials:** 
     - Nitroalkane (H₃C–NO₂) and a ketone with an amine group.
   - **Description:**
     - This reaction involves a nucleophilic addition of the nitroalkane to the iminium ion formed by the reaction of the amine and ketone, typical of the Mannich reaction.

**Graphical Elements:**
- Each reaction is represented with structural formulas showing specific atoms and bonds, highlighting key functional groups involved in each reaction.

These exercises help in understanding key organic reactions, emphasizing mechanism concepts like enolate formation, nucleophilic attack, and condensation processes.
Transcribed Image Text:**Transcription and Explanation for Educational Website** --- **Chemical Reactions: Predicting Major Products** The image presents a series of chemical reactions where the goal is to predict the major product formed in each reaction. Below are the detailed descriptions and conditions for each reaction: 1. **Reaction 1: Aldol Reaction** - **Starting Material:** - A ketone with the formula CH₃C(O)CH₃. - **Reagents and Conditions:** - Sodium hydroxide (NaOH) in aqueous solution (H₂O). - **Description:** - This is a classic aldol reaction where an enolate ion is formed. The enolate then attacks the carbonyl carbon of another molecule of the ketone leading to the aldol product. 2. **Reaction 2: Claisen Condensation** - **Starting Materials:** - A ketone similar to the first reaction, and a cyclic ester (lactone). - **Reagents and Conditions:** - Step 1: Sodium hydride (NaH). - Step 2: Introduction of a carbonyl compound, specifically a cyclic ketone. - Step 3: Hydrochloric acid (HCl), water (H₂O), and heat (Δ). - **Description:** - This is a Claisen condensation involving the deprotonation of the ketone by NaH to form an enolate. The enolate acts as a nucleophile and attacks the carbonyl carbon of the cyclic ester. Finally, hydrolysis under acidic conditions and heat leads to the final product. 3. **Reaction 3: Nitro-Mannich Reaction** - **Starting Materials:** - Nitroalkane (H₃C–NO₂) and a ketone with an amine group. - **Description:** - This reaction involves a nucleophilic addition of the nitroalkane to the iminium ion formed by the reaction of the amine and ketone, typical of the Mannich reaction. **Graphical Elements:** - Each reaction is represented with structural formulas showing specific atoms and bonds, highlighting key functional groups involved in each reaction. These exercises help in understanding key organic reactions, emphasizing mechanism concepts like enolate formation, nucleophilic attack, and condensation processes.
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