FIGURE 17.8 Polson Oak Dermatitis This skin reaction results from delayed-type hypersensitivity. A hapten from poison oak combines with skin proteins. First exposure Subsequent exposures activate memory cells 1 Dendritic cells present the hapten:peptide complex to T cells. 3a Helper T cells activate macrophages presenting hapten:peptide complex. 3b Cytotoxic T cells destroy skin cells presenting hapten:peptide complex. Hapten:peptide Dendritic cell Naive helper T cell Naive cytotoxic T cell Macrophage Skin cell 2 T-cell activation, proliferation, and differentiation increases the population of T cells that recognize the hapten:peptide complex. Cytotoxic T cell Cytokines Helper T cell Naive helper T cell Naive cytotoxic T cell Activated macrophages release inflammatory mediators. 5 A rash appears after 24 hours, reaching a peak at 48–72 hours after exposure. Effector T cells Macrophage Memory cells Inflammatory mediators
FIGURE 17.8 Polson Oak Dermatitis This skin reaction results from delayed-type hypersensitivity. A hapten from poison oak combines with skin proteins. First exposure Subsequent exposures activate memory cells 1 Dendritic cells present the hapten:peptide complex to T cells. 3a Helper T cells activate macrophages presenting hapten:peptide complex. 3b Cytotoxic T cells destroy skin cells presenting hapten:peptide complex. Hapten:peptide Dendritic cell Naive helper T cell Naive cytotoxic T cell Macrophage Skin cell 2 T-cell activation, proliferation, and differentiation increases the population of T cells that recognize the hapten:peptide complex. Cytotoxic T cell Cytokines Helper T cell Naive helper T cell Naive cytotoxic T cell Activated macrophages release inflammatory mediators. 5 A rash appears after 24 hours, reaching a peak at 48–72 hours after exposure. Effector T cells Macrophage Memory cells Inflammatory mediators
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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Why does a sensitized person not experience a skin reaction immediately after exposure to poison oak?
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