fetal and Studies of oxygen transport in pregnant mammals show that the O2-saturation curves maternal blood are markedly different when measured under the same conditions. Fetal erythrocytes contain a structural variant of hemoglobin, HbF, consisting of two a and two y (a2 y2), whereas maternal erythrocytes contains HbA (a2 B2). 1. 1.0 HbF +BPG 0.5 E HbA +BPG 2 4 8 10 pO2 (kPa) a. Which hemoglobin has a higher affinity for oxygen under physiological conditions, HbA or HbF? Explain. b. What is the physiological significance of the different O2 affinities?

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Chapter1: Chemical Foundations
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fetal and
Studies of oxygen transport in pregnant mammals show that the O2-saturation curves
maternal blood are markedly different when measured under the same conditions. Fetal erythrocytes
contain a structural variant of hemoglobin, HbF, consisting of two a and two y (a2 y2), whereas
maternal erythrocytes contains HbA (a2 B2).
1.
1.0
HbF
+BPG
0.5 E
HbA
+BPG
2
4
8
10
pO2 (kPa)
a. Which hemoglobin has a higher affinity for oxygen under physiological conditions, HbA or HbF?
Explain.
b. What is the physiological significance of the different O2 affinities?
Transcribed Image Text:fetal and Studies of oxygen transport in pregnant mammals show that the O2-saturation curves maternal blood are markedly different when measured under the same conditions. Fetal erythrocytes contain a structural variant of hemoglobin, HbF, consisting of two a and two y (a2 y2), whereas maternal erythrocytes contains HbA (a2 B2). 1. 1.0 HbF +BPG 0.5 E HbA +BPG 2 4 8 10 pO2 (kPa) a. Which hemoglobin has a higher affinity for oxygen under physiological conditions, HbA or HbF? Explain. b. What is the physiological significance of the different O2 affinities?
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