Explain how the VERY commonly prescribed medication Lasix, which blocks the NKCC-mediated transporter, works as such a powerful diuretic.  Include the direct effect(s) and the INdirect effect(s) blocking this transporter has on the water retention/concentration abilities of the kidneys - structures affected (nephron sections, kidney structures), etc.

Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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Explain how the VERY commonly prescribed medication Lasix, which blocks the NKCC-mediated transporter, works as such a powerful diuretic.  Include the direct effect(s) and the INdirect effect(s) blocking this transporter has on the water retention/concentration abilities of the kidneys - structures affected (nephron sections, kidney structures), etc.  Also address how this medication may affect sodium and potassium concentrations in the body. 

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