Examine the peptide.Thr‑Lys‑Pro‑Ile‑Val‑Ala‑Pro‑Met‑Glu‑Tyr‑Gly‑LysEstimate the net charge on the peptide at pH 7.Estimate the net charge on the peptide at pH 12. GroupAcidBaseTypical pk,Terminal a-carboxyl3.1groupAspartic acidGlutamic acid4.1N.Histidine6.0+ H-N-NTerminal a-amino group8.0H.CysteineH'-S8.3+ H-N-NTHHLysine10.8Тугosine10.9HHN-HH.NArginine12.5N-HH'N-HH'O-U

The net charge of peptide molecule depends upon the charge on the amino acids side chain, N-terminal…

Answered: Examine the peptide.…

Examine the peptide. Thr‑Lys‑Pro‑Ile‑Val‑Ala‑Pro‑Met‑Glu‑Tyr‑Gly‑Lys Estimate the net charge on the peptide at pH 7. Estimate the net charge on the peptide at pH 12.

Chemistry

10th Edition

ISBN:9781305957404

Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Chapter1: Chemical Foundations

Section: Chapter Questions

Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...

See similar textbooks

Related questions

Q: Write the structural formula (flat projection) of the dipeptide glycyl-phenylalanine (Glycine is the…

A: When the OH group of one amino acid and H of amine group of another amino acid condensed to give a…

Q: 3. The structure below is ß-sheet. Two extended strands of the polypeptide are H-bonded in a…

Q: Which amino acid could act as a general acid catalyst? Aspartate Valine Proline O Tryptophan

A: Amino acids contain carboxylic acid and an amine functional group on the same carbon atom. Amino…

Q: i H H H₂N-CH-C-N-CH-C-N-CH-C-OH + CHCH, CH₂ CHS H water HCI valine 1+ phenylalanine + glycine

A: Amide bond on hydrolysis in acidic medium breaks to give carboxylic acid and amine as products.

Q: (a) Which of the common amino acids have more than one carboxyl group?

A: Amino acids having more than one carboxylic acid (-COOH) group are acidic amino acids.

Q: When an amino acid has a negative charge coming from the carboxylic acid or a positive charge coming…

A: Explanation: The point at which an amino acid has no net electrical charge is known as its…

Q: Below is the structure of a hypothetical photo-affinity probe analogue of the anti- malarial drug…

A: Cross-links with nearby proteins in the presence of UV light. B is the correct answer.

Q: Write the structure for the protein Pro-Asn-Tyr-Cys at pH 7.0.

A: Amino acid: An amino acid is an organic molecule and it consists of amine group (NH2), acidic…

Q: Of the four sequences below, one can be that of a peptide, others can't. Which is the one that can…

Q: H₂N Peptide 1 NH NH₂ H --NH2 Peptide 2 Peptide 3 SH அய்ந்த வந்தர்

A: The given peptides consists of several natural amino acids linked together by amide linkage. We can…

Q: Write the structures of the peptides given below. 1. Pro-His-Ala 2. Met-Cys-Tyr

A: A peptide bond is an amide-type bond between two amino acids. An amino acid contains amino and…

Q: 1.Draw Fischer projection formulas for the following amino acids. L-Serine D-Serine…

Q: Q1. Eticlopride is a dopamine antagonist, which can block dopamine receptor sites and influence…

Q: Provide the correct primary structure for the following nonapeptide. If any of the amino acid…

Q: α-Amino acids can be prepared by treating an aldehyde with ammonia/trace acid, followed by hydrogen…

A: α-Amino acids is prepared by treating 3-methylbutanal with ammonia/trace acid, followed by hydrogen…

Q: What bonding/interaction(s) is possible between octane derivatives and peptides? O Cation-to-Anion O…

Q: Reaction of the a-carboxyl group of an amino acid or peptide with phenylisothiocyanate allows for…

Q: If a heptapeptide is made of Y-P-G-P-H-I-L amino acid sequence, what qualitative tests will give…

A: When acid hydrolysis of bond polypeptide is done then the peptide bond joining the amino acid in…

Q: Draw Tryptophan in a peptide bond. Explain all of the bonds using valence bond theory (VBT). Next,…

Q: Which of the following is not one of the 20 common amino acids used in protein synthesis? O Glycine…

A: It is based on the concept of amino acid. Here we are required to find the species which is not…

Q: 7. The Twinkle protein (shown as a long oval below) can be modified with a lipid. Which of the…

A: Fatty acids consist of long hydrocarbon chain with a carboxylic acid group (-COOH) at one end. The…

Q: NH2 (CH2)4 H (CH2)4 H (CH,)4 H CH3 NH, NH, HC(CH3)2 H CH2 amino H>N—C-С-N-С-С—N—С-С—N—С-С-N—С—СООН…

A: We will choose correct option

Q: At the lowest energy level a-helix of polypeptide chain is stabilised By hydrogen bonds formed…

Q: consider the peptide show но но но но но .. .. .. +H3N-C-C-N-C-C-N-с-с-N-c-ё-N-с-с-о- I . Н H CH3 H…

A: see below

Q: Combine the following proteins into one polypeptide. Draw out the new organic molecule TYROSINE…

Q: Which of the statements concerning the peptide shown below is FALSE? H2 H3N-C C-N-C- H -O- H2C CH2…

A: The Structure is mainly composed of 3 Peptide molecules (Tripeptide) : Glycine, Proline, and Serine.…

Q: TRUE OR FALSE: Naturally-occurring amino acids have the L- configuration. All amino acids are chiral…

Q: Locate all of these in picture amino ion , carboxyl ion , side chain and a carbon

A: Interpretation - We have to locate all of these which is given as - amino ion , carboxyl ion , side…

Q: lodoacetamide acts as an irreversible inhibitor for a few enzymes by reacting with the amino acid at…

A: The objective of the question is to identify the functional group in an amino acid that reacts with…

Q: Pick the statement that best predicts the amino acid’s physical properties. Large dipole moments…

Q: The primary difference between each amino acid is _____. the side chain (functional group) of…

A: The amino acid is the building block of proteins. Amino acids are polar compounds because of charge…

Q: Given the following tripeptide, determine the tertiary interaction for each amino acid present. In…

A: Amino acids are the building blocks of proteins. Proteins are the long chains of amino acids…

Q: H₂N ОН NH₂ NH товидце Н H₂N ОН NH₂ H2N, НО NH₂ NH₂ ОН ОН NH₂ НО NH₂ довдив оч ОН ОН EN NH₂ NH₂ НО…

A: Amino acids are molecules that combine to form proteins. Amino acids and proteins are the building…

Q: The net charge on the following amino acid is [x] at pH 10. HS NH₂ ОН

A: Given is amino acid.The name of given amino acid is cysteine.

Q: Vhich of the following amino acid categories probably woul e comfortable in aqueous environments? )…

A: The question is based on the concept of amino acids. we have to talk about different amino acids and…

Q: Explain why casein is not denatured by the addition of acid (unlike most proteins).

A: Denaturation of proteins means the breaking of bonds (hydrogen bonds) within the protein molecule…

Q: For the following hexapeptide shown below, answer the following questions. E-N-D-Y-K-L Draw the…

A: Hexapeptide given is: E-N-D-Y-K-L

Q: 8. Which type of cross-link would form between the following amino acids? HO TI H₂N-C-C-OH HO-CH CH₂…

A: is called serine is called threonine

Q: Lanthionine is a nonstandard amino acid consisting of two alanine residues linked via their β carbon…

A: Structure of lanthionine is,

Q: Which would have the smallest percentage of polar amino acids?

A: solution- answer of this question is given below step;

Q: peptide has the sequence

A: peptide sequence is:…

Q: Which chemical group is a hydrogen-bond acceptor that stabilizes an alpha-helical peptide?

A: Hydrogen bond are very specific in nature. Only formed with H atom attach to more electronegative…

Q: Hyrophobic region in lipid is a carbolic group at end of lipid molecules. O False True

A: Hydrophobic region in lipid is carboxylic group at the end of lipid molecules:

Q: Draw the structure of the following molecule The amino acid phenylalanine at pH 1

Q: Which is an essential amino acid for infants and children due to their rapid growth? Glutamine…

A: amino acid is an organic compound made of two functional groups -NH2 And -COOH groups, amino acid…

Question

100%

Examine the peptide.

Thr‑Lys‑Pro‑Ile‑Val‑Ala‑Pro‑Met‑Glu‑Tyr‑Gly‑Lys

Estimate the net charge on the peptide at pH 7.

Estimate the net charge on the peptide at pH 12.

Group
Acid
Base
Typical pk,
Terminal a-carboxyl
3.1
group
Aspartic acid
Glutamic acid
4.1
N.
Histidine
6.0
+ H
-N
-N
Terminal a-amino group
8.0
H.
Cysteine
H'
-S
8.3
+ H
-N
-N
TH
H
Lysine
10.8
Тугosine
10.9
H
H
N-H
H.
N
Arginine
12.5
N-H
H'
N-H
H'
O-U

Expert Solution

This question has been solved!

Explore an expertly crafted, step-by-step solution for a thorough understanding of key concepts.

This is a popular solution!

SEE SOLUTION Check out a sample Q&A here

Step 1

Step 2

Step 3

Step 4

Trending now

This is a popular solution!

Step by step

Solved in 4 steps

SEE SOLUTION Check out a sample Q&A here

Similar questions

How do you deprotect the side-chain carboxyl under mild conditions without removing the BOC-protecting group at the same time?
What process results in cleavage of peptide linkages in a protein? O esterification O hydrolysis O denaturating O hydrogen bonding
Explain about cysteine residues. How many cysteine residues a α-Keratins has ?
Draw the chemical structure and give the one and three letter symbols for an amino acid fitting each of these descriptions: Has a positive charge at pH 7.0 Has a neutral charge at pH 7.0 Contains 3 nitrogen atoms Contains an aromatic ring Contains an alcohol group which is NOT part of a carboxylic acid group
What tertiary interaction would be expected between the following amino acids OH H,N-CH OH CH-CH3 CH2 ČH, O covalent bond O electrostatic attraction O hydrogen bonding O hydrophobic O no tertiary interaction expected
This amino acid would be more likely to bind to a receptor inside of the cell. COO- H3N-C-H CH2 CH2 CH2 CH2 *NH3 True O False This amino acid would be more likely to bind to a receptor inside of the cell. COO H3N-C-H H-C-CH3 CH2 CH3 O True O False
Which statement is NOT true about a peptide bond? O The peptide bond is longer than the typical carbon-nitrogen bond. CO The carbonyl oxygen and the amide hydrogen are most often in a frans configuration with respect to another. O Rotation is restricted about the peptide bond. The peptide bond has partial double-bond character.
can you list out the homolugous series and functional group for Anthocyanidins and Pelargonidin-3-Glucoside. Thankyou
Two of the amino acids have two chiral centers. Give the name and three-letter abbreviation of each. Enter your answers separated by a comma.Enter your answers separated by a comma.
3
The methyl group on C5 of thymidylate is donated by A、Alanine B、SAM C、N5-methyl THF D、N5,N10-methylene THF
What is the net charge of serine at a pH of 1? At a pH of 7? At a pH of 14? HO х H2N OH