Ex: A 70 Kg patient is to be given oubain by Lv. infusion. The drug has a half-life of 22 hours, apparent Vd 15.7liters and the desired Steady-State plasma concentration is 0.0002 mcg/ml. Assuming one-compartment kinetics, calculate 1-time required reaching 90% of Css? 3- the loading dose to attain the Css rapidly? e 10:40

Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
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Ex: A 70 Kg patient is to be given oubain
by Lv. infusion. The drug has a half-life
of 22 hours, apparent Vd 15.7liters
and the desired Steady-State plasma
concentration is 0.0002 mcg/ml.
Assuming one-compartment kinetics,
calculate 1-time required reaching 90%
of Css? 3- the loading dose to attain the
Css rapidly?
e 10:40 /
Transcribed Image Text:Ex: A 70 Kg patient is to be given oubain by Lv. infusion. The drug has a half-life of 22 hours, apparent Vd 15.7liters and the desired Steady-State plasma concentration is 0.0002 mcg/ml. Assuming one-compartment kinetics, calculate 1-time required reaching 90% of Css? 3- the loading dose to attain the Css rapidly? e 10:40 /
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