Epoxides are highly strained and can alleviate the strain by reacting under acidic and basic conditions to give different regiochemical and stereochemical products. In this epoxide tutorial, we will cover 1. ring opening of unsubstituted epoxide 2. which nucleophiles will open an epoxide 3. regiochemical and stereochemical results of basic ring opening of asymmetrical epoxides 4. regiochemical and stereochemical results of acidic ring opening Step 3: If the nucleophilic attack takes place on a chiral epoxide, an inversion of configuration is observed. Consider the epoxide ring-opening of a chiral epoxide. 1. NaSH ? 2. H₂O Select the product or products of the reaction. SH SH SH JOH ...OH OH OH .....SH

Q: What change would you expect on the rate of the Sy2 reaction of 1-lodo-2methylbutane with cyanide…

A: The rate of the SN2 reaction of 1-iodo-2-methylbutane with cyanide ion remains unchanged  if the…

Q: p. q. Cl₂ (excess) Br₂

A: Organic reactions are those in which organic reactant react to form organic products. In the given…

Q: Through what basic mechanism is 1-methylcyclohexanol converted to 1-brom methylcyclohexane upon…

A: Basic mechanism is 1-methylcyclohexanol converted to 1-bromo-1- methylcyclohexane upon treatment…

Q: 15. Which of the following correctly describes the relative nucleophilicities of methoxide and tert-…

A: Nucleophilicity is defined as the ease of donation of electrons by the electron rich species to the…

Q: Compound 2 Me0z OʻK+ Compovnd3 Compound 4 compound 1

A: Robinson Annulation is Michael addition followed by intramolecular Aldol condensation.

Q: List the alkyl halides in order of decreasing reactivity towards the Sn1 reaction

A: SN1 reactions proceed via formation of carbocation in a first order reaction in which the reactivity…

Q: Rank the derivatives of tert-cumyl chloride in order of increasing reactivity in this solvolysis.…

A: Solvolysis is a process in which halide substituted through SN1 reaction.

Q: NH, 1) CI 2) Br, (might also require catalytic FeBr3) 3) H300 NH2 [H°] + NABH3CN

A:

Q: a,B-Unsaturated carbonyls act as electrophile starting materials in reactions. What positions in an…

A: Given carbonyl compound,

Q: 0. Rank the following molecules in order of decrea H I CF3 O F- II CF3 FO H3C III CH3 FO

A: This is general question from general organic chemistry.more the partial positive developed at…

Q: What major product will be formed when the shown Grignard reagent is combined with the shown…

A: Given reaction,

Q: How many different aldol addition products can be formed in the reaction of equ amounts of propanal…

A: We have to make all possible combinations during aldol addition, aldol addition can happen between…

Q: Question 10: Identify which reagents you would use to achieve the following transformations. a. b.…

A: First example is a reaction of protection of -OH group by p-toulene sulfonyl chloride.Second and…

Q: bJ HCl, traue peroxides

A: Which of these is the best reagent to affect the transformation? (a) HCl (b) HCl, peroxides (c)…

Q: Specify the reaction conditions to favour the indicated elimination mechanism. a. Strong base, such…

A:

Q: Which TWO allylic carbocations would give kinetic products?

A: Given compound is: Which double bond reacts faster with HBr and form the product?

Q: Example #1: b a Example #2: a b Predict the substitution pattern when this compound undergoes a…

A: "Since you have posted multiple questions,we will provide the solution only for first question as…

Q: Which benzylic halide reacts faster in an SN1 reaction? Explain.

A: From among the two benzylic halide given we can tell that the halide A reacts much faster than…

Q: Given the following reaction involving a diene and dienophile answer the following questions. A.…

A: To solve the problem, we need to address the following parts: Part A: Drawing the Two Possible…

Q: 3. Circle the nucleophile in each pair that undergoes SN2 reaction most rapidly with Ph-CH2-Cl in…

A:

Q: Provide mechanistic pathway for each step and the products based on the reagents selected. Diels…

A: We have to give the product of the each step with the mechanism. The given steps are Step 1:…

Q: 10. Propose a synthesis of the diene using cis-but-2-ene as your only sources of carbon atoms.

A: The synthesis of given diene is,

Q: Which of these nucleophiles would be the best for converting a tertiary alkyl halide into an…

A: Nucleophilic substitution is that type of reaction in which electron rich nucleophile attacks the…

Q: Put the following carbonyl compounds in order of decreasing reactivity towards nucleophiles (i.e.…

A:

Q: What is the best way to remeber the differences between Sn1, Sn2, E1 and E2 reations?

A: The best way to remember differences between SN1,  SN2, E1 and E2 reaction is that

Reactions of Ethers

Ethers (R-O-R’) are compounds formed by replacing hydrogen atoms of an alcohol (R-OH compound) or a phenol (C6H5OH) by an aryl/ acyl group (functional group after removing single hydrogen from an aromatic ring). In this section, reaction, preparation and behavior of ethers are discussed in the context of organic chemistry.

Epoxides

Epoxides are a special class of cyclic ethers which are an important functional group in organic chemistry and generate reactive centers due to their unusual high reactivity. Due to their high reactivity, epoxides are considered to be toxic and mutagenic.

Williamson Ether Synthesis

An organic reaction in which an organohalide and a deprotonated alcohol forms ether is known as Williamson ether synthesis. Alexander Williamson developed the Williamson ether synthesis in 1850. The formation of ether in this synthesis is an SN2 reaction.