e) Which step in the sequence is rate determining and why? f) What is the mechanism of the reaction? g) Which of the following reactions will be faster and why? H20 H20 Br Br
Catalysis and Enzymatic Reactions
Catalysis is the kind of chemical reaction in which the rate (speed) of a reaction is enhanced by the catalyst which is not consumed during the process of reaction and afterward it is removed when the catalyst is not used to make up the impurity in the product. The enzymatic reaction is the reaction that is catalyzed via enzymes.
Lock And Key Model
The lock-and-key model is used to describe the catalytic enzyme activity, based on the interaction between enzyme and substrate. This model considers the lock as an enzyme and the key as a substrate to explain this model. The concept of how a unique distinct key only can have the access to open a particular lock resembles how the specific substrate can only fit into the particular active site of the enzyme. This is significant in understanding the intermolecular interaction between proteins and plays a vital role in drug interaction.

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Consider the following reaction co-ordinate diagram
H20
H20
Br
A
D
Energy
Reaction Co-ordinate
a) Identify the various species on the diagram by adding the letter identifying each of the
structures.
b) Which species does the first transition state of the overall reaction most resemble? What
kind of transition state is this?
c) Which species does the second transition state of the overall reaction most resemble?
What kind of transition state is this?"
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