Answered: Drug Kp (M) A 0.02 x 10-6 B 7.01 x 10-6…

Introduction to Chemical Engineering Thermodynamics

8th Edition

ISBN:9781259696527

Author:J.M. Smith Termodinamica en ingenieria quimica, Hendrick C Van Ness, Michael Abbott, Mark Swihart

Publisher:J.M. Smith Termodinamica en ingenieria quimica, Hendrick C Van Ness, Michael Abbott, Mark Swihart

Chapter1: Introduction

Section: Chapter Questions

Problem 1.1P

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Question

Affinity of drugs to a given receptor.
Different drug candidates are analyzed to determine their affinity to a given receptor. Measured equilibrium dissociation constants arelisted in the following table. Rank-order the drug candidates from highest affinity to weakest affinity for the receptor.

Drug
Kp (M)
A
0.02 x 10-6
B
7.01 x 10-6
0.20 x 10-6

Expert Solution

Step 1

The binding affinity of ligand for its target depends on the equilibrium dissociation constant K_D. The higher the value of K_D, the lower will be the binding affinity. The given binding affinities are:

Step 2

The increasing order of K_Dis:

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