Drinking methanol can cause blindness in humans, as well as a severe acidosis that may be life threatening. Methanol is toxic because it is converted in the liver to formaldehyde and formic acid by the enzymes alcohol dehydrogenase and aldehyde dehydrogenase. Methanol poisoning is treated with dialysis and infusions of bicarbonate and ethanol. Explain why each treatment is used.

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Chapter1: Chemical Foundations
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Drinking methanol can cause blindness in humans, as well as a severe acidosis that may be life
threatening. Methanol is toxic because it is converted in the liver to formaldehyde and formic acid
by the enzymes alcohol dehydrogenase and aldehyde dehydrogenase. Methanol poisoning is
treated with dialysis and infusions of bicarbonate and ethanol. Explain why each treatment is used.

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