**Title: Understanding Mixed Claisen Ester Condensation****Objective:** Learn how to draw the most stable form of the major mixed Claisen product formed in the given reaction.**Reaction Overview:**- **Reactants:** - Two esters, a propionate ester and an ethyl acetate. - **Reagents:** 1. Sodium ethoxide (NaOC₂H₅) 2. Acidic workup (H₃O⁺)- **Solvent:** Ethanol (C₂H₅OH)**Mechanism Explanation:**1. **Deprotonation:** Sodium ethoxide (NaOC₂H₅) deprotonates the alpha-hydrogen of one of the esters, forming an enolate ion.2. **Nucleophilic Attack:** The enolate ion attacks the carbonyl carbon of the other ester, leading to the formation of a β-keto ester intermediate.3. **Protonation:** Acidic workup (H₃O⁺) protonates the alkoxide intermediate, resulting in the stable Claisen condensation product.**Structural Insight:**- Both ester groups participate in the reaction, but the more substituted enolate is typically favored in mixed Claisen reactions.- The major product is a β-keto ester.**Key Learning Points:**- Recognize how mixed Claisen condensations form key carbon-carbon bonds.- Understand the role of each reagent and solvent in the mechanism.- Predict the structure of the Claisen product by considering enolate formation and nucleophilic acyl substitution.This reaction is integral in organic synthesis, providing a pathway to create complex molecules from simple ester precursors. Understanding this process aids in mastering broader synthetic strategies in chemistry.

Claisen condensation is the reaction in which enolates are added to an ester molecule. Enolate is…

Answered: Draw the most stable form of the major…

Draw the most stable form of the major mixed Claisen product formed in the reaction. Select Draw Rings 1. NaOC2H5 2. H3O* C2H5OH +

Chemistry

10th Edition

ISBN:9781305957404

Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Chapter1: Chemical Foundations

Section: Chapter Questions

Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...

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Concept explainers

Alkanes and Cycloalkanes

Alkanes are saturated organic compounds which are made up of C and H atoms. Alkanes have the general formula of CnH2n+2. Alkane contains sp3 hybridized carbon atoms with four sigmas (σ) bonds & every hydrogen atom is connected with one of the carbon atoms. The size of the alkane could be determined by the number of carbon atoms located in it.

Question

**Title: Understanding Mixed Claisen Ester Condensation**

**Objective:**
Learn how to draw the most stable form of the major mixed Claisen product formed in the given reaction.

**Reaction Overview:**

- **Reactants:**
- Two esters, a propionate ester and an ethyl acetate.

- **Reagents:**
1. Sodium ethoxide (NaOC₂H₅)
2. Acidic workup (H₃O⁺)

- **Solvent:** Ethanol (C₂H₅OH)

**Mechanism Explanation:**

1. **Deprotonation:**
Sodium ethoxide (NaOC₂H₅) deprotonates the alpha-hydrogen of one of the esters, forming an enolate ion.

2. **Nucleophilic Attack:**
The enolate ion attacks the carbonyl carbon of the other ester, leading to the formation of a β-keto ester intermediate.

3. **Protonation:**
Acidic workup (H₃O⁺) protonates the alkoxide intermediate, resulting in the stable Claisen condensation product.

**Structural Insight:**

- Both ester groups participate in the reaction, but the more substituted enolate is typically favored in mixed Claisen reactions.
- The major product is a β-keto ester.

**Key Learning Points:**

- Recognize how mixed Claisen condensations form key carbon-carbon bonds.
- Understand the role of each reagent and solvent in the mechanism.
- Predict the structure of the Claisen product by considering enolate formation and nucleophilic acyl substitution.

This reaction is integral in organic synthesis, providing a pathway to create complex molecules from simple ester precursors. Understanding this process aids in mastering broader synthetic strategies in chemistry.

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