Draw a structural formula for the major ionic form of the amino acid shown below when in aqueous solution at pH 3.0. H N N H -CH₂CHCOH *NH3 histidine • You do not have to consider stereochemistry. You do not have to explicitly draw H atoms. • Do not include lone pairs in your answer. They will not be considered in the grading. Sn [F

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Chapter1: Chemical Foundations
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**Instructions for Drawing Histidine at pH 3.0:**

To represent the major ionic form of histidine in an aqueous solution at pH 3.0, consider the following structural details:

1. **Chemical Structure of Histidine:**
   - The amino acid histidine features an imidazole side chain. 
   - At pH 3.0, the amino group (NH2) is protonated (NH3^+), and the carboxyl group (COOH) is likely uncharged. The imidazole ring may also become protonated due to the low pH.

2. **Diagram Overview:**
   - The diagram includes the backbone structure of histidine with its amine and carboxyl groups.
   - The imidazole ring is shown attached to the side chain.

3. **Annotation Guidelines:**
   - You do not need to consider stereochemistry, simplifying the drawing process.
   - Hydrogen atoms (H) attached to carbon (C) need not be explicitly drawn.
   - Exclude lone pairs from your drawing as they are not required for grading.

**Using the Drawing Tool:**
   - Utilize the drawing tool provided below the instructions to create the structural formula. The toolbar includes options for drawing atoms, bonds, and structures necessary to represent the molecule.

By following these guidelines, you can accurately depict the ionic form of histidine in conditions present at pH 3.0.
Transcribed Image Text:**Instructions for Drawing Histidine at pH 3.0:** To represent the major ionic form of histidine in an aqueous solution at pH 3.0, consider the following structural details: 1. **Chemical Structure of Histidine:** - The amino acid histidine features an imidazole side chain. - At pH 3.0, the amino group (NH2) is protonated (NH3^+), and the carboxyl group (COOH) is likely uncharged. The imidazole ring may also become protonated due to the low pH. 2. **Diagram Overview:** - The diagram includes the backbone structure of histidine with its amine and carboxyl groups. - The imidazole ring is shown attached to the side chain. 3. **Annotation Guidelines:** - You do not need to consider stereochemistry, simplifying the drawing process. - Hydrogen atoms (H) attached to carbon (C) need not be explicitly drawn. - Exclude lone pairs from your drawing as they are not required for grading. **Using the Drawing Tool:** - Utilize the drawing tool provided below the instructions to create the structural formula. The toolbar includes options for drawing atoms, bonds, and structures necessary to represent the molecule. By following these guidelines, you can accurately depict the ionic form of histidine in conditions present at pH 3.0.
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