DNA polymerase contains an arginine residuethat is important for binding to DNA.Mutations were found that converted thisarginine to either glutamate, lysine, glycineand valine. Which mutations would bepredicted to be the most and least harmfulfor the activity of the enzyme to bind DNA?Most: Glutamate, least: LysineMost: Lysine, least: GlutamateMost: Glycine, least: ValineMost: Valine, least: Glycine.

DNA polymerase contains an arginine residue that is important for binding to DNA. Mutations were…

Answered: DNA polymerase contains an arginine…

Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

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Galactosemia is a metabolic disorder characterized by the inability to metabolize the sugar galactose. People with galactosemia suffer from liver, kidney, and brain damage among other symptoms. A gene mutation underlying galactosemia was identified by sequencing the genome of a person with galactosemia. What additional evidence would support the hypothesis that the mutation in the candidate gene causes the disease?
A molecular researcher, Dr. Sidra Alkatini, is investigating the manifestation of a disorder in some of her lab mice models, which are lacking production of an important protein necessary for the cellular respiration pathway. The afflicted mice are short lived, and have perpetually low blood glucose levels, no matter how much food they are fed. Through sequencing, the following strand of DNA was produced: 5’ TTC CAA TTA CGC CGC TAT ACG CGC ACC ATG TTA TCA TGT TGG TGG TAG 3’ Given your expertise in genetics, she contacts you, her BFF, to help her understand the sequence and its relation to the genetic disorder she is seeing. 1) What motif in this DNA sequence would serve as the RBS? a Essentially none; this is a eukaryotic sequence, so the RBS will be made up of the methylated G-cap! b CAAT! c ACCATGG! d TATA! 2) Do you notice anything unusual about this transcript? a YES! It is very short! b YES! It is…
Is there any situation in which DNA is made based on a RNA template? What is the enzyme involved?
Which statement is true for the active site residues of RNase A, lysozyme, or trypsin? Select any/all answers that apply. O A. His12 (RNase A) initially acts as an acid. O B. His119 (RNase A) initially acts as an acid. O C. Glu35 (lysozyme) initially acts as an acid. O D. His57 (trypsin) initially acts as an acid. O E. Ser195 (trypsin) initially acts as an acid.
How are deoxyribonucleoside triphosphates (precursors of daughter DNA strands) and ribonucleoside triphosphates (precursors of RNA strand) differ from each other?
If the following nucleotide sequence, CTC/TGT/AAG/ACC/TTT experienced a mutation resulting in the deletion of the second cytosine in the first DNA triplet so the sequence is now CT_/TGT/AAG/ACC/TTT, what would be the amino acid sequence created from this mutated DNA strand? Table of mRNA codons UUA, UUG = leucine AGG, AGA = arginine %3D CAU, CAC = histidine GUU, GÜC, GUA = valine GAA. GAG=glutamic acid GCU, GUA, GUG = alanine GAU, GAC = asparagine GGU, GGC, GGA = glycine UCA, UCU =serine CGU, CGC, CGA = arginine
Which of the following statements most accurately describes the action of the enzyme RNA polymerase?Select one 1.) RNA polymerase will transcribe only the exons by skipping over the introns within a eukaryotic gene sequence 2.) RNA polymerase will transcribe both DNA strands, moving in the 3' to 5' direction for one strand and 5' to 3' on the other 3.) RNA polymerase will transcribe both DNA strands, but only one RNA molecule will be used during translation 4.)None of the statements accurately describe the function of RNA polymerase
While the three previous paragraphs put on some details about enzymes, a Russian physician and chemist named Phoebus Levene focused on the three major components of a single nucleotide (phosphate, pentose sugar, and nitrogenous base) in 1919. He was also the first to discover the carbohydrate component of RNA (ribose), and carbohydrate component of DNA (deoxyribose). Years later, Levene finally identified how DNA and RNA molecules are put together Then in 1937, Hans Krebs discovered the most famous (probably) process that occur during cell respiration. This series of chemical reactions has three names such as the Citric Acid Cycle, Tricarboxylic Acid Cycle and Krebs Cycle. In this process, glucose and oxygen is converted to carbon dioxide, water, and energy. While working on bacterial samples, Oswald Avery first suggested in 1944 that the genetic material of the cell was possibly the deoxyribonucleic acid. In the middle of the 20th Century, Erwin Chargaff began to oppose Levene's…
Given the following diagram of how protein AWESOME1 binds to it's target DNA, describe the potential effects of each of the 5 mutations shown below. The wild-type sequence of a helix #1 is also shown in the blue box, and all the mutations are in helix #1 (see numbers for identifying particular residues). a helix #1 R(1)-V-I-L-Y-F-W-I-M-Y-F-S-H-Y-W-R(16) #1 Predict the consequence of the following mutations: 1) Arg(1) to Glu 2) Arg(1) to Ala 3) Phe(6) to lle 4) Trp(7) to Phe 5) Met(9) to Pro in

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