Determine the major product(s) of the following reaction: :0: HNO H2SO, :0: NO2 O2N :0: NO2 :OH

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# Nitration of Aromatic Compound: Identifying the Major Products

The following image is a question regarding the nitration reaction of an aromatic compound. We are required to determine the major product(s) formed when the given substrate reacts with a nitrating mixture.

## Reaction Scheme

The original aromatic compound is acetophenone, illustrated as follows:

- Benzene ring (C6H5) with a keto group (C=O) and a methyl group (CH3), collectively forming the acetophenone structure.

The compound undergoes nitration using a mixture of nitric acid (HNO3) and sulfuric acid (H2SO4).

## Given Multiple Choices for the Major Product(s):

Several structures are presented as potential products of this reaction. Let's describe each possibility.

1. **Option 1**: 
    - Structure: Benzene ring with a keto group (C=O) at the first carbon (meta to NO2) and a nitro group (NO2) attached to the second carbon.
    - Position: 2-Nitroacetophenone (ortho-nitration product).

2. **Option 2**:
    - Structure: Benzene ring with a keto group (C=O) at the first carbon, and a nitro group (NO2) attached to the third carbon.
    - Position: 3-Nitroacetophenone (meta-nitration product).

3. **Option 3**:
    - Structure: Benzene ring with a keto group (C=O) at the first carbon, and a nitro group (NO2) attached to the fourth carbon.
    - Position: 4-Nitroacetophenone (para-nitration product).

4. **Option 4**:
    - Structure: Benzene ring with a keto group (C=O) at the first carbon, an OH group at the first carbon (second part of the ester functional group), and a nitro group (NO2) attached to the second carbon.
    - Position: Ortho-position to a modified acetophenone structure.

## Explanation of Nitration Reaction

Nitration, typically performed using a mixture of nitric acid and sulfuric acid, introduces a nitro group (NO2) to an aromatic ring. The position of nitration on the benzene ring depends on the directing effects of existing substituents:

- The keto group (C=O) in acet
Transcribed Image Text:# Nitration of Aromatic Compound: Identifying the Major Products The following image is a question regarding the nitration reaction of an aromatic compound. We are required to determine the major product(s) formed when the given substrate reacts with a nitrating mixture. ## Reaction Scheme The original aromatic compound is acetophenone, illustrated as follows: - Benzene ring (C6H5) with a keto group (C=O) and a methyl group (CH3), collectively forming the acetophenone structure. The compound undergoes nitration using a mixture of nitric acid (HNO3) and sulfuric acid (H2SO4). ## Given Multiple Choices for the Major Product(s): Several structures are presented as potential products of this reaction. Let's describe each possibility. 1. **Option 1**: - Structure: Benzene ring with a keto group (C=O) at the first carbon (meta to NO2) and a nitro group (NO2) attached to the second carbon. - Position: 2-Nitroacetophenone (ortho-nitration product). 2. **Option 2**: - Structure: Benzene ring with a keto group (C=O) at the first carbon, and a nitro group (NO2) attached to the third carbon. - Position: 3-Nitroacetophenone (meta-nitration product). 3. **Option 3**: - Structure: Benzene ring with a keto group (C=O) at the first carbon, and a nitro group (NO2) attached to the fourth carbon. - Position: 4-Nitroacetophenone (para-nitration product). 4. **Option 4**: - Structure: Benzene ring with a keto group (C=O) at the first carbon, an OH group at the first carbon (second part of the ester functional group), and a nitro group (NO2) attached to the second carbon. - Position: Ortho-position to a modified acetophenone structure. ## Explanation of Nitration Reaction Nitration, typically performed using a mixture of nitric acid and sulfuric acid, introduces a nitro group (NO2) to an aromatic ring. The position of nitration on the benzene ring depends on the directing effects of existing substituents: - The keto group (C=O) in acet
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