Detailed mechanism of reaction of compound 5 with phosphorous tribromide to give compound 3

Chemistry
10th Edition
ISBN:9781305957404
Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
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Detailed mechanism of reaction of compound 5 with phosphorous tribromide to give compound 3 

A retrosynthetic analysis of 1 was undertaken suggesting a forward synthesis starting from
compounds 2, 5 and 6.
OH
F3C
F3C.
H2N
Br
A (a)
(b)
NH2
1
HO
6.
(b)
Compound (5) is reacted with phosphorous tribromide (PBR3) to give intermediate
(3), Write down a detailed mechanism for this conversion.
21
Transcribed Image Text:A retrosynthetic analysis of 1 was undertaken suggesting a forward synthesis starting from compounds 2, 5 and 6. OH F3C F3C. H2N Br A (a) (b) NH2 1 HO 6. (b) Compound (5) is reacted with phosphorous tribromide (PBR3) to give intermediate (3), Write down a detailed mechanism for this conversion. 21
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