D H d. DMF D H CI Ét Ét R`N H D your mechanism has to account for the complete retention of stereochemistry as the chiral carbon

Chemistry
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ISBN:9781305957404
Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Chapter1: Chemical Foundations
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Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...
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supply mechanisms for the following reactions showing all intermediates, all formal charges, and use arrows to show electron flow

**Chemical Reaction and Stereochemistry**

This diagram illustrates a chemical reaction involving chiral molecules and emphasizes the importance of maintaining stereochemistry at a chiral center. 

### Reaction Components:

1. **Reactants:**
   - The left side of the arrow shows a compound featuring a six-membered aromatic ring bonded to a nitrogen atom. The nitrogen is further connected to an ethyl group (Et), a chiral carbon, and a chlorine atom (Cl).
   - The chiral carbon is labeled with an R configuration and is bonded to deuterium (D), hydrogen (H), and another hydrogen (H), maintaining its chiral nature.
   - The other reactant is a molecule with a five-membered nitrogen-containing aromatic ring (pyridine derivative).

2. **Solvent:**
   - The reaction is carried out in dimethylformamide (DMF), depicted above the arrow indicating the reaction.

### Reaction Product:

- The resulting product consists of the same aromatic ring with nitrogen, retaining the ethyl and chiral carbon. However, the chlorine is replaced by the nitrogen-containing aromatic ring from the second reactant.
- The product also retains the R configuration at the chiral center, indicated by the stereochemistry notation.

### Stereochemistry:

- The text emphasizes the necessity of accounting for complete retention of the stereochemistry at the chiral carbon during the reaction.

**Note:** This reaction may involve specific mechanisms, such as nucleophilic substitution, where the stereochemistry must remain unchanged. Understanding these mechanisms is crucial for students studying organic chemistry and reactions involving chiral molecules.
Transcribed Image Text:**Chemical Reaction and Stereochemistry** This diagram illustrates a chemical reaction involving chiral molecules and emphasizes the importance of maintaining stereochemistry at a chiral center. ### Reaction Components: 1. **Reactants:** - The left side of the arrow shows a compound featuring a six-membered aromatic ring bonded to a nitrogen atom. The nitrogen is further connected to an ethyl group (Et), a chiral carbon, and a chlorine atom (Cl). - The chiral carbon is labeled with an R configuration and is bonded to deuterium (D), hydrogen (H), and another hydrogen (H), maintaining its chiral nature. - The other reactant is a molecule with a five-membered nitrogen-containing aromatic ring (pyridine derivative). 2. **Solvent:** - The reaction is carried out in dimethylformamide (DMF), depicted above the arrow indicating the reaction. ### Reaction Product: - The resulting product consists of the same aromatic ring with nitrogen, retaining the ethyl and chiral carbon. However, the chlorine is replaced by the nitrogen-containing aromatic ring from the second reactant. - The product also retains the R configuration at the chiral center, indicated by the stereochemistry notation. ### Stereochemistry: - The text emphasizes the necessity of accounting for complete retention of the stereochemistry at the chiral carbon during the reaction. **Note:** This reaction may involve specific mechanisms, such as nucleophilic substitution, where the stereochemistry must remain unchanged. Understanding these mechanisms is crucial for students studying organic chemistry and reactions involving chiral molecules.
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