CO0- | CH, CO0- CO2 CH, CH2 CH, C=0 C=0 CO0- H a-Ketoglutarate Succinate semialdehyde

Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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Certain microorganisms with a modified citric acid cycle decarboxylate a-ketoglutarate to produce succinate semialdehyde:

(a) Succinate semialdehyde is then converted to succinate, which is further
metabolized by standard citric acid cycle enzymes. What kind of reaction
is required to convert succinate semialdehyde to succinate? Show
any coenzymes that might be involved.
(b) Based on your answer in part a, how does this pathway compare to the
standard citric acid cycle in energy yield?

CO0-
|
CH,
CO0-
CO2
CH,
CH2
CH,
C=0
C=0
CO0-
H
a-Ketoglutarate
Succinate semialdehyde
Transcribed Image Text:CO0- | CH, CO0- CO2 CH, CH2 CH, C=0 C=0 CO0- H a-Ketoglutarate Succinate semialdehyde
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