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Consider the following mechanism: What kind of reaction is occurring during this step of glycolysis? What metabolite is in Box 1? What metabolite is in Box 2? What metabolite is in Box 3? What enzyme catalyzes this reaction

Consider the following mechanism: What kind of reaction is occurring during this step of glycolysis? What metabolite is in Box 1? What metabolite is in Box 2? What metabolite is in Box 3? What enzyme catalyzes this reaction

Biochemistry
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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  1. Consider the following mechanism:
    1. What kind of reaction is occurring during this step of glycolysis?
    2. What metabolite is in Box 1?
    3. What metabolite is in Box 2?
    4. What metabolite is in Box 3?
    5. What enzyme catalyzes this reaction?
    6. Circle and label one place on the mechanism where covalent catalysis is occurring.
    7. Suggest an amino acid that could fill the role of residue “A” in the mechanism above and draw its structure at pH 7.4.
    8. Suggest an amino acid that could fill the role of residue “B” in the mechanism above and draw its structure at pH 7.4.
    9. Under standard conditions, this reaction is unfavorable (DG¢° = 23.8 kJ/mol). What conditions in the cell allow for the actual free energy change to be lower (DG » 0), making the reaction readily reversible? Explain your answer.

*please help and explain as well as you can*

ÇH,OPO ÇH,OPO3- Кн но H Он ÓH H Вох 1 CH,OPO- | CH,OPO}- H 'CH,OPO- H+ H20 H Lys-N:2c-0 H H. -N*-0-H :A- CH+ Lys-N*=¢ "H-A– :A- HO³CH :B- н носн HOCH :B- :B- H*C-0-H -B:) HÇ-0-H нсон CH,OPO3- -BH ! НСОН -B: HECOH CH,OPO3- CH,OPO;- Вох 2 Вох 3 H. CH,OPO C=0 HÇOH CH,OH CH,OPO3- H Lys-N: H CH,OPO3- H. Lys-N*=¢ ÇH,OPO3- Lys-N-C H20 :A- H-A- :A- Ho-c-H :B- H-B- H-B- -B: -B: -B-H
Transcribed Image Text:ÇH,OPO ÇH,OPO3- Кн но H Он ÓH H Вох 1 CH,OPO- | CH,OPO}- H 'CH,OPO- H+ H20 H Lys-N:2c-0 H H. -N*-0-H :A- CH+ Lys-N*=¢ "H-A– :A- HO³CH :B- н носн HOCH :B- :B- H*C-0-H -B:) HÇ-0-H нсон CH,OPO3- -BH ! НСОН -B: HECOH CH,OPO3- CH,OPO;- Вох 2 Вох 3 H. CH,OPO C=0 HÇOH CH,OH CH,OPO3- H Lys-N: H CH,OPO3- H. Lys-N*=¢ ÇH,OPO3- Lys-N-C H20 :A- H-A- :A- Ho-c-H :B- H-B- H-B- -B: -B: -B-H
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