cleoside triphosphates ... a) are synthesized from nucleoside monophosphates using the energy of ATP hydrolysis. b) always contain the nitrogenous base adenine. c) lose their two terminal phosphates in exergonic polymerization reactions that form nucleic acids. d) a and c
Nucleoside triphosphates ...
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Nucleoside triphosphates are flexible molecules that can be functionalized in a variety of ways. The protein polymerization of those modified triphosphate analogs provides a versatile platform for the production of (highly) functionalized nucleic acids in a simple and gentle manner. Various altered triphosphates are used in a wide range of applications, including DNA tagging and labeling as well as the production of catalytic nucleic acids.
The significance of (2'-deoxy)ribonucleoside triphosphates [(d)NTPs] in a variety of biological activities should not be overstated. Natural (d)NTPs, for example, serve as the basic building blocks for polymerase-mediated nucleic acid synthesis in vitro and in vivo, while nucleotide serves as the universal unit of molecular currency. Changed triphosphates are the ultimate and active type of deoxyribonucleic acid enzyme and reverse transcriptase inhibitors, so they are the focus of a variety of artificial campaigns.
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