Answered: Chromosomal DNA (human) 41% G + C…

Human Anatomy & Physiology (11th Edition)

11th Edition

ISBN:9780134580999

Author:Elaine N. Marieb, Katja N. Hoehn

Publisher:Elaine N. Marieb, Katja N. Hoehn

Chapter1: The Human Body: An Orientation

Section: Chapter Questions

Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...

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Huntington’s disease is a hereditary central nervous system disorder characterized by tandem repeats of the sequence 5'-CAG-3' in the gene that encodes a protein called huntingtin. The disease is progressive from generation to generation, meaning that in later generations the number of CAG repeats increases and the age of onset of symptoms decreases. Refer to Figure 21.4 and describe the sort of evidence supporting the generational increase in the number of CAG repeats.

Chromosomal DNA
(human)
41% G + C
Satellite DNA
CAG repeat
67% G + C
Shear during DNA isolation
Centrifuge to
equilibrium in CsCI
Density
A260
Bottom
Top
A FIGURE 21.4 Satellite DNA. Shearing high-molecular-weight DNA
yields short fragments that have distinctive densities and can be sepa-
rated in a CsCI gradient.

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