Epoxides are highly strained and can alleviate the strain by reacting under acidic and basic conditions to give different regiochemical and stereochemical products. In this epoxide tutorial, we will cover 1. ring opening of unsubstituted epoxide 2. which nucleophiles will open an epoxide 3. regiochemical and stereochemical results of basic ring opening of asymmetrical epoxides 4. regiochemical and stereochemical results of acidic ring opening Step 1: In a simple unsubstituted epoxide, a nucleophile can attack the epoxide and open the ring to give an alcohol after aqueous workup. HO: -:Nuc 2. H₂O Nuc Common nucleophiles that will undergo this reaction include alkoxides, nitriles, thiols, carbanions, acetylides, Grignard reagents and lithium aluminum hydride. Which is not a product that can be formed from epoxide ring opening? HOCH₂CH₂OH HOCH₂CH₂C=N CH₂CH₂CH₂OH OCH, OCH₂CH₂OCH,

Epoxides are highly strained and can alleviate the strain by reacting under acidic and basic conditions to give different regiochemical and stereochemical products. In this epoxide tutorial, we will cover 1. ring opening of unsubstituted epoxide 2. which nucleophiles will open an epoxide 3. regiochemical and stereochemical results of basic ring opening of asymmetrical epoxides 4. regiochemical and stereochemical results of acidic ring opening Step 1: In a simple unsubstituted epoxide, a nucleophile can attack the epoxide and open the ring to give an alcohol after aqueous workup. HO: -:Nuc 2. H₂O Nuc Common nucleophiles that will undergo this reaction include alkoxides, nitriles, thiols, carbanions, acetylides, Grignard reagents and lithium aluminum hydride. Which is not a product that can be formed from epoxide ring opening? HOCH₂CH₂OH HOCH₂CH₂C=N CH₂CH₂CH₂OH OCH, OCH₂CH₂OCH,

Chemistry

10th Edition

ISBN:9781305957404

Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Chapter1: Chemical Foundations

Section: Chapter Questions

Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...

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