The following structure is more active than morphine as an analgesic. HO -NMe H. acetyl O The extra acetyl group interacts with an extra binding region within the binding site by acting as a hydrogen bond acceptor O The extra acetyl group masks a polar group allowing the structure to cross cell membranes more efficiently O The extra acetyl group masks an alcohol group which would otherwise undergo a phase Il metabolic conjugation reaction leading to rapid excretion of the drug. O The extra acetyl group masks a polar group allowing the structure to cross the blood brain barrier more efficiently.

The following structure is more active than morphine as an analgesic. HO -NMe H. acetyl O The extra acetyl group interacts with an extra binding region within the binding site by acting as a hydrogen bond acceptor O The extra acetyl group masks a polar group allowing the structure to cross cell membranes more efficiently O The extra acetyl group masks an alcohol group which would otherwise undergo a phase Il metabolic conjugation reaction leading to rapid excretion of the drug. O The extra acetyl group masks a polar group allowing the structure to cross the blood brain barrier more efficiently.

Chemistry

10th Edition

ISBN:9781305957404

Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Chapter1: Chemical Foundations

Section: Chapter Questions

Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...

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