(@) (€) Complete the following synthesis road map by (i) providing the structures of the major organic compound(s) in boxes (C), (D), (G), (H), and (I1). (ii) Provide the reagents required to complete each transformation in boxes (a), (b), (e), and (f). separated by chiral column chromatography and taken foward as a single isomer 1) (a) Start Here H. (C) Na OEt Br 2) (a) + enantiomer 1. NaNH2 1) (e) (a) 2. OEt Br + a diastereomer 2) (3) 1) Na (metal), NH3 2) Cl2, DCM 1) O3, -78°c 2) DMS (1) Hints for completing road each pathway closely (there are 3 different question). When/if you get stuck on maps: Follow (H) this pathways in a. forward transformation, look down a pathway for information about the next structure

(@) (€) Complete the following synthesis road map by (i) providing the structures of the major organic compound(s) in boxes (C), (D), (G), (H), and (I1). (ii) Provide the reagents required to complete each transformation in boxes (a), (b), (e), and (f). separated by chiral column chromatography and taken foward as a single isomer 1) (a) Start Here H. (C) Na OEt Br 2) (a) + enantiomer 1. NaNH2 1) (e) (a) 2. OEt Br + a diastereomer 2) (3) 1) Na (metal), NH3 2) Cl2, DCM 1) O3, -78°c 2) DMS (1) Hints for completing road each pathway closely (there are 3 different question). When/if you get stuck on maps: Follow (H) this pathways in a. forward transformation, look down a pathway for information about the next structure

Chemistry

10th Edition

ISBN:9781305957404

Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Chapter1: Chemical Foundations

Section: Chapter Questions

Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...

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Over the past several decades, chemists have developed a number of synthetic methodologies for the synthesis of steroid hormones. One of these, developed by Lutz Tietze at the Institut für Organische Chemie der Georg-August-Universität, Göttingen, Germany, used a double Heck reaction to create ring B of the steroid nucleus. As shown in the following retrosynthetic analysis, a key intermediate in his synthesis is compound (1). Two Heck reaction disconnects of this intermediate give compounds (2) and (3). Compound (2) contains the aromatic ring that becomes ring A of estrone. Compound (3) contains the fused five- and six-membered rings that become rings C and D of estrone. Q.Show how your proposals for compounds (2) and (3) can be converted to compound (1). (Note: In the course of developing this synthesis, Tietze discovered that vinylic bromides and iodides are more reactive in Heck reactions than are aryl bromides and iodides.)
12:01 PM Wed Nov 17 * 65% T +: 0 Complete the following synthesis road map by (i) providing the structures of the major organic compounds in boxes (A), (B), (C), (D), and (E). (ii) Provide the reagents required to complete each transformation in boxes (a), (b), and (c). Start Here ((a) NaNH2 (excess) ((A) Br Et Br TARGET 2 (C) Br2, CH;OH OMe (c) Na |(B) H. + + enantiomer + enantiomer (b) (D) 1) NaNH2 2) EtBr Draw 1 Isomer Here Draw 2 Stereoisomers Here TARGET 1 OMe + enantiomer OMe TARGET 3 Na (metal), NH3 SMe SMe 1) Оз, -78°C 2) DMS Hints for completing road maps: Follow each OMe (E) pathway closely (there are H, 3 different pathways in this + question). When/if you get stuck on a transformation, look forward down a + enantiomer + enantiomer pathway for information about the next structure 10
Give detailed Solution with explanation needed..don't give Handwritten answer..give rection mechanism
3. a) b) c) d) Answer ALL parts a) - d). A Structure Activity Relationship (SAR) study has been used to design heterocyclic compound 8, a selective antagonist of adenosine receptors. fel Provide reagents, reaction conditions and a curly arrow mechanism for the three component reaction to synthesise compound 8, starting from compound 9. NH₂ Indicate the stereocentre in 8 and suggest an approach toward its enantiopure production. of NH₂ Suggest reagents for steps A and C, and the structure of the intermediate B required to prepare the enaminoester 9. 10 Suggest a one-step method D (including reagents and conditions), to transform compound 8 into compound 10. State the type of reaction and the names of the two heterocyclic rings in 8 and in 10, respectively.
19) (1) Predict the major product(s) of the hydration reaction depicted below, specifying the major stereoisomer(s). Provide a mechanism for the transformation that justifies your response. Name the product(s) including absolute stereochemistry assignments where relevant, and provide a 1-2 sentence/pictorial explanation justifying your name(s). Hint: aqueous (aq) sulfuric acid contains a majority of water. t H₂SO4 (aq) 7. ?
(b) (i) Ethyl acetoacetate D is a versatile reagent for the synthesis of a wide range of ketones. Suggest reagents and conditions which could be used to convert D into E and F. D OEt E Ph Ph F (ii) Explain your chosen synthetic route to compound E with the aid of reaction mechanisms.
Do (c) it as early as possible.
(a) When toluene (methyl benzene) is sulfonated through reaction with concentrated H2SO4 at room temperature, predominantly (~ 95% of total) ortho- and para-substitution occurs. If elevated reaction temperatures (150 – 200°C) and longer reaction times are employed, meta- (chiefly) and para-substitution account for 95% of the products. Provide a rationale for this finding using words and reaction schemes.
4. Answer the following questions based in the scheme below: (i) Determine the principle involved in the following conversion, either chemoselective, regioselective, or stereoselective. (ii) Write the synthetic steps, and provide all suitable reagents.
Last two questions under 1 please