Cells maintain different steady state ratios of \(NAD^+/NADH\) (1000) and \(NADP^+/NADPH\) (0.01).(a) How do these ratios relate to the metabolic functions of \(NAD^+\) and \(NADPH\)?(b) Given these physiological ratios, what is the \(\Delta G\) for \(NAD^+\) to oxidize \(NADPH\)?(c) This reaction does *not* happen in most tissues. Make a hypothesis: what prevents this from occurring?

NAD+ is the oxidized version. NAD+ accepts two electrons and a proton to get reduced to NADH.NAD+ +…

Answered: Cells maintain different steady state…

Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

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How come high levels of NADH indicate reduced coenzymes rather than oxidized coenzymes? Isn't pyruvate oxidized by the reduction of NAD+ to NADH? Why is the answer reduced then?
Calcium is an important regulator of the citric acid cycle. Calcium is transported across the mitochondrial inner membrane by a Ca²- 2+ uniporter that is driven by the negative potential inside the matrix. Part A Assuming a membrane potential across the inner membrane of 172 mV (inside negative), calculate the ratio of the [Ca2+] in the matrix to that in the cytoplasm ([Ca2+]m/[Ca²+]c) that would exist at equilibrium (i.e., AG = 0). Express your answer using two significant figures. [Ca2+]m [Ca2+] = ΤΟ ΑΣΦ Submit Request Answer Part B ? Cytoplasmic [Ca2+] is on the order of 10-7 M in a healthy cell. Based on your answer in Part A, calculate the [Ca2+] that would exist in the matrix at equilibrium. Express your answer to two significant figures and include the appropriate units. ☐ μÅ ? Value Units
Place the following components of the electron-transport chain in their proper order: (a) cytochrome c (b) Q-cytochrome coxidoreductase (c) NADH-Q reductase (d) cytochrome c oxidase (e) ubiquinone
Calculate the ΔG for Malate dehydrogenase reaction of CAC if the concentration of oxaloacetate is 1x 10-8 M, malate is 0.2 mM, NAD+ is 10 mM and NADH is 0.1 mM in rat liver mitochondria. ΔGo’ for this reaction is 30 kJ/mole. Please write the units of the final answer and the formula you are using to solve. R = 0.008314kJ/K*mol, T = 298K

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