Cathy is pregnant for the second time. Her first child, Donald, has cystic fibrosis. Cathy has two brothers Charles and Colin, and a sister, Cindy. Colin and Cindy are unmarried. Charles is married to an unrelated woman, Carolyn, and has a 2-year old daughter, Debbie. Cathy's parents are Bob and Betty. Betty's sister Barbara is the mother of Cathy's husband, Calvin, who is 25. There is no previous family history of CF. Assume that everyone in this family is of Northern European Origin. A. Sketch the pedigree, using standard symbols. B. What is the pattern of transmission of CF, and what is the risk for CF for Cathy's next child? C. Which people in this pedigree are compound heterozygotes?

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