Bob and Will are monozygotic (identical) twins. They are 18 years old and in their first year the liberal arts college that their parents attended. Their parents are Robert Senior (age 55) and Jane (age 48). They had one miscarriage during the first pregnancy. Bob and Will have a younger sister (Su, age 12). 11 months after the birth of Su, Jane had a second miscarriage. Jane was adopted by her parents and has an unknown history of her birth family. Robert Senior parents are Samuel (age 88) and Mary (deceased at age 60 from a stroke). Both Samuel and Mary smoked cigarettes since age 18 and Samuel has COPD and uses supplemental oxygen. Robert Senior has two brothers, Nick (age 56) and Tony (52). Tony is incarcerated for multiple car thefts. He has a history of violent behavior. Both Bob and Will have been experimenting with drugs at college. In the last month or so, Bob’s work has fallen off. He has not been completing assignments at his usual high level of quality. His thoughts seem to have become disorganized, and he mentions to Will that he has been hearing voices telling him that he should abandon school because the administration is working for an unfriendly foreign government. After much difficulty, Bob is diagnosed with schizophrenia. 1. Sketch an informal pedigree for this family but do not submit for this case. What are significant risk factors that are observed (include individuals in your response). 2. What is Will’s risk of schizophrenia? 3. Would Will benefit from talking with a genetic counselor? 4. Should Will have genetic testing to see if he will get schizophrenia?
Bob and Will are monozygotic (identical) twins. They are 18 years old and in their first year the liberal arts college that their parents attended. Their parents are Robert Senior (age 55) and Jane (age 48). They had one miscarriage during the first pregnancy. Bob and Will have a younger sister (Su, age 12). 11 months after the birth of Su, Jane had a second miscarriage. Jane was adopted by her parents and has an unknown history of her birth family. Robert Senior parents are Samuel (age 88) and Mary (deceased at age 60 from a stroke). Both Samuel and Mary smoked cigarettes since age 18 and Samuel has COPD and uses supplemental oxygen. Robert Senior has two brothers, Nick (age 56) and Tony (52). Tony is incarcerated for multiple car thefts. He has a history of violent behavior.
Both Bob and Will have been experimenting with drugs at college. In the last month or so, Bob’s work has fallen off. He has not been completing assignments at his usual high level of quality. His thoughts seem to have become disorganized, and he mentions to
Will that he has been hearing voices telling him that he should abandon school because the administration is working for an unfriendly foreign government. After much difficulty, Bob is diagnosed with schizophrenia.
1. Sketch an informal pedigree for this family but do not submit for this case. What are significant risk factors that are observed (include individuals in your response).
2. What is Will’s risk of schizophrenia?
3. Would Will benefit from talking with a genetic counselor?
4. Should Will have genetic testing to see if he will get schizophrenia?
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