vny can acetone sometimes be detected in thebreath of patients with type 1 diabetes?A. Glucagon signaling is faulty,leading to an excess ofoxaloacetate, which enablesacetyl-CoA to enter the citric acidcycle, therefore resulting in theproduction of ketone bodiesincluding acetoneOB. Insulin signaling is faulty, soexcess malonyl-CoA is generated,which leads to excess acetyl-CoAfrom beta oxidationOc. None of the other answers iscorrectOD. Insulin signaling is correct, butexcess acetyl-CoA is generatedanyway, leading to the productionof ketone bodies includingacetoneO E. Insulin signaling is faulty, fattyacids are catabolized to acetyl-COA despite high blood glucose,and excess acetyl-CoA isconverted to ketone bodies,

Type 1 diabetes occurs when blood glucose level increases because of the improper or non-functional…

Answered: can acetone sometimes be detected in…

Biochemistry

6th Edition

ISBN:9781305577206

Author:Reginald H. Garrett, Charles M. Grisham

Publisher:Reginald H. Garrett, Charles M. Grisham

Chapter22: Gluconeogenesis, Glycogen Metabolism, And The Pentose Phosphate Pathway

Section: Chapter Questions

Problem 8P

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Similar questions

The antidiabetes drugs known as thiazolidinediones induce the production of glycerol kinase in adipocytes. Explain why this would decrease the concentration of serum fatty acids, which are often elevated in diabetics.
Stimulation of a certain Gs protein–coupled receptor activates protein kinase A (PKA). Predict the eff ect of PKA activation on the following substrates of PKA: (a) acetyl-CoA carboxylase, (b) glycogen synthase, (c) hormone-sensitive lipase, and (d) phosphorylase kinase.
Discuss the metabolic rationale for phosphorylation of acetyl-CoA carboxylase by AMP-activated protein kinase (AMPK) and cyclic AMP-dependent protein kinase (PKA).
Explain why insulin is required for adipocytes to synthesize triacylglycerols from fatty acids.
Glucagon secretion inhibits intracellular acetyl-CoA carboxylase activity through a number of different methods. Make a list of everything that comes to mind.
In the fasted state, FADH2 and NADH for oxidative phosphorylation are mainly provided by fatty acid oxidation. Explain how fatty acids are mobilised from adipose tissue by the action of glucagon.
Compare the localization of GLUT4 with that of GLUT2 and GLUT3, and explain why these localizations are important in the response of muscle,adipose tissue, brain, and liver to insulin
Diabetes mellitus is characterized by insufficiency of thepancreas to produce enough insulin to regulate the blood sugarlevel. In type I diabetes, the pancreas produces no insulin, andthe patient is totally dependent on insulin from an externalsource to be infused at a rate to maintain blood sugar levelsat normal levels. Hyperglycemia occurs when blood glucoselevel rises much higher than the norm (>8 mmol/L) for pro-longed periods of time; hypoglycemia occurs when the blood sugar level falls below values of 3 mmol/L. Both situations canbe deleterious to the individual’s health. The normal range ofblood sugar is between 3.8 and 5.6 mmol/L, the target rangefor a controller regulating blood sugar.A patient with type I diabetes needs your help to maintainher blood sugar within an acceptable range (3 mmol/L<glucose<8 mmol/L). She has just eaten a large meal (a disturbance) that you estimate will release glucose accord-ing toD(t)=0.5e−0.05t,wheretis in minutes andD(t)is inmmol/L –…
Explain the indirect effect that allosteric effectors have on pyruvate dehydrogenase activity through phosphorylation/dephosphorylation of components within the PDH-complex.
. Glucagon secretion causes inhibition of intracellular acetyl-CoA car- boxylase activity by several mechanisms. Name all you can think of.
Pancreatic β cells express a receptor for fatty acids. Fatty acid binding to the protein appears to stimulate insulin secretion. Does this phenomenon make metabolic sense?
Chemistry which of these are insulin and which are glucagon.

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can acetone sometimes be detected in the breath of patients with type 1 diabetes?