c. The structure of the acid 1.2 is shown below. The pKas for the deprotonation sites are also shown on the structure. 4.5 HO 10.2 HS 1.2 OH 3.1 1. Structure 1.2 is observed at pHs less than 2.0. In this form, acid 1.2 can be considered as a triprotic acid. Hand-draw the three individual balanced equilibrium reactions showing the sequential deprotonation of 1.2. Include an image of your equilibrium reactions ii. Sketch an approximate speciation curve for acid 1.2. Your sketch should include appropriate labels stating the pKa values, titles for each axis and you should clearly label each species curve. iii. Identify the species of acid 1.2 that is expected to be the dominant form at a pH of around 7.4, the pH found in human cells and blood. iv. Calculate the pH range at which the concentration of the species in part (c)(iii) will be at least 10 times higher than that of any other species. Explain your reasoning.

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c. The structure of the acid 1.2 is shown below. The pKas for the deprotonation sites are
also shown on the structure.
4.5 HO
10.2 HS
O
1.2
0
OH 3.1
i. Structure 1.2 is observed at pHs less than 2.0. In this form, acid 1.2 can be
considered as a triprotic acid. Hand-draw the three individual balanced
equilibrium reactions showing the sequential deprotonation of 1.2. Include an
image of your equilibrium reactions
ii. Sketch an approximate speciation curve for acid 1.2. Your sketch should include
appropriate labels stating the pKa values, titles for each axis and you should
clearly label each species curve.
HILIETIE
iii. Identify the species of acid 1.2 that is expected to be the dominant form at a pH of
around 7.4, the pH found in human cells and blood.
iv. Calculate the pH range at which the concentration of the species in part (c)(iii) will
be at least 10 times higher than that of any other species. Explain your reasoning.
Transcribed Image Text:c. The structure of the acid 1.2 is shown below. The pKas for the deprotonation sites are also shown on the structure. 4.5 HO 10.2 HS O 1.2 0 OH 3.1 i. Structure 1.2 is observed at pHs less than 2.0. In this form, acid 1.2 can be considered as a triprotic acid. Hand-draw the three individual balanced equilibrium reactions showing the sequential deprotonation of 1.2. Include an image of your equilibrium reactions ii. Sketch an approximate speciation curve for acid 1.2. Your sketch should include appropriate labels stating the pKa values, titles for each axis and you should clearly label each species curve. HILIETIE iii. Identify the species of acid 1.2 that is expected to be the dominant form at a pH of around 7.4, the pH found in human cells and blood. iv. Calculate the pH range at which the concentration of the species in part (c)(iii) will be at least 10 times higher than that of any other species. Explain your reasoning.
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