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- Cancer Cells need A.I.R in order to survive and proliferate. What does this stand for? a. Activation of TSG's; Inactivation of oncogene; Replenishing of Telomeres b. Absorption of oncogenes; Inactivation of TRK's; Replenishing of Telomeres c. Activation of oncogenes; Inactivation of TGF's; Replenishing of Telomeres d. Activation of oncogene; Inactivation of TSG's; Replenishing of Telomeresg protein D. Growth factor receptor ng Tool 0 Q ing C. Growth factor-binding protein D. Growth factor receptor E. Transcription activator A child with retinoblastoma is found to have a 13q14 deletion. The Rb gene, which resides at this locus, produces which kind of tumor-associated protein? A. Cell cycle regulator B. Growth factor ㅂ분 요 9 12 W □ @ 2 C Edit in Paint 8 60 8 FocusIn a suppressor interaction, produce(s) a protein complex that is O a. 1 mutation, active b. 1 mutation, inactive С. 2 mutations, active d. 2 mutations, inactive
- Role of Myc activation is the follows a. It directly inhibits Rb protein through phosphorylation b. It stimulates assembly of S-phase Cdk-cyclin complex c. It stimulates transcription of delayed response genes d. It increases the expression of early response genes Role of Myc activation is the follows a. It directly inhibits Rb protein through phosphorylation b. It stimulates assembly of S-phase Cdk-cyclin complex c. It stimulates transcription of delayed response genes d. It increases the expression of early response genes1. VHL is a tumor suppressor because a. it causes cancer cells to become hypoxic b. it inhibits the enzyme proline hydroxylase c. it promotes the degradation of a powerful transcription factor. d. in the absence of VHL, HIF-1 is ubiquitylated by proline hydroxylase 2. NF-1 is a tumor suppressor because A. it inactivates Ras by promoting the hydrolysis of GTP to GDP B. it promotes the methylation of the Ras gene promoter C. it is a phosphatase that dephosphorylates the kinases in the Ras effector pathways D. it inhibits the GEF (guanine exchange factor) that activates Ras please answer both question cause this is my last posting question thank youA tumor suppressor gene regulates the cell cycle; an example is . Select one: a. positively, p21 b. negatively, cyclin c. positively, retinoblastoma d. negatively, retinoblastoma e. positively, RAS Cycle HW due Jump to. 4) Next pa cancer stem cells
- Tumor suppressor genes O become oncogenes when a "gain-of-function" mutation occurs O are classified as "gatekeepers" or "caretakers" O will be deactivated if only one copy of the allele is mutated all responses are correctWhen a gene is normally not transcribed a. it cannot be up- or downregulated b. it can be negatively regulated c. it can be negatively autoregulated d. it can be positively regulated e. it is constitutively expressedA. Somatic cells are aslo called B. In irder to clone a gene, a gene is inserted into a:
- Match the gene on the left with the gene category on the right. ERBB2 E-cadherin BRCA1 Cdk4 A. oncogene B. proto-oncogene C. low expression in invasive cells D. tumor suppressor geneSelect all of the statements that apply to transcytosis. A. Transfers dimeric IgG B. Transfers dimeric IgA C. Utilizes the poly-Ig receptor D. Utilizes the Brambell receptor E. Two receptors must bind to move the Ab F. Protease is used to release the Ab after it has moved G. Change in pH is used to release the Ab after it has moved H. Transfers monomeric IgAWe have studied Ras signal transduction pathway. In an experiment, two different mutations were produced using different chemicals. The proteins with mutation are listed below. State what will be the effect of each mutation and explain whether it will result in cell proliferation or not. GEF protein GTPase