Below is an image of how biotin is used in the reaction that converts pyruvate to oxaloacetate, an important metabolic reaction. The overall reaction is: Bicarbonate + ATP + pyruvate--> Oxaloacetate + ADP Which statement below is correct regarding biotin? HO Bicarbonate HN NH Biotin Enz ATP Enol pyruvate ADP 2. coo $100 NH Ent Carboxybiotin coo C-o CH₂ Cooo Oxaloacetate HỘI NH Biotin O a. Biotin is a cofactor that serves as a reducing agent and is important for the generation of collagen
Below is an image of how biotin is used in the reaction that converts pyruvate to oxaloacetate, an important metabolic reaction. The overall reaction is: Bicarbonate + ATP + pyruvate--> Oxaloacetate + ADP Which statement below is correct regarding biotin? HO Bicarbonate HN NH Biotin Enz ATP Enol pyruvate ADP 2. coo $100 NH Ent Carboxybiotin coo C-o CH₂ Cooo Oxaloacetate HỘI NH Biotin O a. Biotin is a cofactor that serves as a reducing agent and is important for the generation of collagen
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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![Below is an image of how biotin is used in the reaction that converts pyruvate to oxaloacetate, an important metabolic reaction.
The overall reaction is:
Bicarbonate + ATP + pyruvate --> Oxaloacetate + ADP
Which statement below is correct regarding biotin?
[Diagram explanation]
The diagram illustrates the enzymatic reaction that involves biotin. The key stages depicted in the diagram include:
1. **Bicarbonate** (depicted by a dotted structure with HO-C(=O)-O) initially.
2. **Biotin** binds with the enzyme (denoted as Enz) and activates it.
3. **ATP** is used, converting to **ADP** releasing energy (ATP + ADP depicted).
4. The enzyme-biotin complex interacts with pyruvate (Enol pyruvate, shown with its chemical structure CH3-C(=O)-C(=O)-O).
5. Finally, the product **Oxaloacetate** is formed (COO-C(=O)-CH2-C(=O)-O).
The accompanying diagrams visualize the chemical transformations and enzyme interactions that facilitate this reaction.
Which statement below is correct regarding biotin?
- a. Biotin is a cofactor that serves as a reducing agent and is important for the generation of collagen.
- b. Biotin is a prosthetic group where the nitrogen serves as an electrophile and bicarbonate is a nucleophile.
- c. Biotin is a cofactor that is covalently linked to the enzyme; the enzyme is a ligase.
---
This explanation is designed to aid understanding of the role biotin plays in this essential biochemical pathway.](/v2/_next/image?url=https%3A%2F%2Fcontent.bartleby.com%2Fqna-images%2Fquestion%2Fcab27ebe-ca52-4065-95ad-a0b64c44780e%2Fcd60b622-b9ba-49d2-8a12-ce53aea4a5e7%2Fkscdahk_processed.jpeg&w=3840&q=75)
Transcribed Image Text:Below is an image of how biotin is used in the reaction that converts pyruvate to oxaloacetate, an important metabolic reaction.
The overall reaction is:
Bicarbonate + ATP + pyruvate --> Oxaloacetate + ADP
Which statement below is correct regarding biotin?
[Diagram explanation]
The diagram illustrates the enzymatic reaction that involves biotin. The key stages depicted in the diagram include:
1. **Bicarbonate** (depicted by a dotted structure with HO-C(=O)-O) initially.
2. **Biotin** binds with the enzyme (denoted as Enz) and activates it.
3. **ATP** is used, converting to **ADP** releasing energy (ATP + ADP depicted).
4. The enzyme-biotin complex interacts with pyruvate (Enol pyruvate, shown with its chemical structure CH3-C(=O)-C(=O)-O).
5. Finally, the product **Oxaloacetate** is formed (COO-C(=O)-CH2-C(=O)-O).
The accompanying diagrams visualize the chemical transformations and enzyme interactions that facilitate this reaction.
Which statement below is correct regarding biotin?
- a. Biotin is a cofactor that serves as a reducing agent and is important for the generation of collagen.
- b. Biotin is a prosthetic group where the nitrogen serves as an electrophile and bicarbonate is a nucleophile.
- c. Biotin is a cofactor that is covalently linked to the enzyme; the enzyme is a ligase.
---
This explanation is designed to aid understanding of the role biotin plays in this essential biochemical pathway.
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