Based on the chemical structure, predict how permeable a biological membrane will be to ethanol (in the absence of a transporter/channel)?

Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
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Cytosol
Mitochondrion
A. PATHWAY 1.
major
pathway of
ethanol
metabolism
NAD* NADH + H*
NAD* NADH + H*
in the liver CH,-CH,-OH ADH + CH,-C=O
CH;-C-OH + H-O-H
ALDH
ETHANOL
ACETALDEHYDE
АСЕТАТЕ
WATER
B. PATHWAY 2
microsomal
ethanol
CYP2E1
oxidizing
system
(MEOS)
NADPH + H* + O2
NADP* + 2H,O
Excess alcohol consumption increases the NADH:NAD* ratio in the cytosol of hepatocytes.
Transcribed Image Text:Cytosol Mitochondrion A. PATHWAY 1. major pathway of ethanol metabolism NAD* NADH + H* NAD* NADH + H* in the liver CH,-CH,-OH ADH + CH,-C=O CH;-C-OH + H-O-H ALDH ETHANOL ACETALDEHYDE АСЕТАТЕ WATER B. PATHWAY 2 microsomal ethanol CYP2E1 oxidizing system (MEOS) NADPH + H* + O2 NADP* + 2H,O Excess alcohol consumption increases the NADH:NAD* ratio in the cytosol of hepatocytes.
Q3: Based on the chemical structure, predict how permeable a biological membrane will be
to ethanol (in the absence of a transporter/channel)?
Transcribed Image Text:Q3: Based on the chemical structure, predict how permeable a biological membrane will be to ethanol (in the absence of a transporter/channel)?
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