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Assume that for a certain pesticide, the LD50 dosage level for laboratory rats is determined to be 450 mg/kg of body mass. 1. Calculate the amount of pesticide that would be considered safe for animals to ingest. 2. What amount of pesticide would be considered safe for humans to ingest?

Assume that for a certain pesticide, the LD50 dosage level for laboratory rats is determined to be 450 mg/kg of body mass. 1. Calculate the amount of pesticide that would be considered safe for animals to ingest. 2. What amount of pesticide would be considered safe for humans to ingest?

Human Anatomy & Physiology (11th Edition)
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
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Estimating LD50 Values and Safe Exposures Using our knowledge of how scientists conduct LD50 studies, we can consider a example. Let's imagine that you are a scientist charged with determining the sare levels for mammals of a pesticide in the environment, Using lab rats, you feed than diet that contains different amounts of the pesticide, ranging from 0 to 4 mg of pesticide per kg of the rat's mass. After feeding them these diets for 4 days. you coont how many rats are still alive, When you plot the data, you obtain the graph below. 100 75 50- 25 3. Pesticide consumed (mg/kg of body mass) What is the LD50 value for lab rats? To determine this, we can draw a horizontal line at the point of 50 percent mortality on the y axis. Where this line intersects the purple line, we can draw another line straight down to the x axis. This second line CTOSses the x axis at 2 mg/kg of mass. Based on this LD50 study, what amount of pesticide would be considered safe for mammais to ingest? Recall that we can calculate this number by taking the LD50 value and dividing it by 10. Thus the safe amount of pesticide for a rat is: 2 mg/kg of mass 0.2 mg/kg of mass 10 Percent mortality
Transcribed Image Text:Estimating LD50 Values and Safe Exposures Using our knowledge of how scientists conduct LD50 studies, we can consider a example. Let's imagine that you are a scientist charged with determining the sare levels for mammals of a pesticide in the environment, Using lab rats, you feed than diet that contains different amounts of the pesticide, ranging from 0 to 4 mg of pesticide per kg of the rat's mass. After feeding them these diets for 4 days. you coont how many rats are still alive, When you plot the data, you obtain the graph below. 100 75 50- 25 3. Pesticide consumed (mg/kg of body mass) What is the LD50 value for lab rats? To determine this, we can draw a horizontal line at the point of 50 percent mortality on the y axis. Where this line intersects the purple line, we can draw another line straight down to the x axis. This second line CTOSses the x axis at 2 mg/kg of mass. Based on this LD50 study, what amount of pesticide would be considered safe for mammais to ingest? Recall that we can calculate this number by taking the LD50 value and dividing it by 10. Thus the safe amount of pesticide for a rat is: 2 mg/kg of mass 0.2 mg/kg of mass 10 Percent mortality
Assume that for a certain pesticide, the LD50 dosage level for laboratory rats is determined to be 450 mg/kg of body mass. 1. Calculate the amount of pesticide that would be considered safe for animals to ingest. 2. What amount of pesticide would be considered safe for humans to ingest? For questions 3 and 4 use the graph below
Transcribed Image Text:Assume that for a certain pesticide, the LD50 dosage level for laboratory rats is determined to be 450 mg/kg of body mass. 1. Calculate the amount of pesticide that would be considered safe for animals to ingest. 2. What amount of pesticide would be considered safe for humans to ingest? For questions 3 and 4 use the graph below
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