Antacids such as calcium carbonate act simply to neutralize stomach acid, thus raising the pH of the stomach juices. This provides temporary relief from heartburn. 2.A second class of compounds, including the drugs Zantac, Pepcid, and Tagamet, act as receptor antagonists of histamine receptors that triggers the release of H+ /K+ ATPase pump by a cascade of reaction. (hint: spicy food – acidity, tomatoes trigger the release of histamine). What happens when you take Zantac what will it do to the pump? 3.The third type, which includes Prilosec and Prevacid, directly inhibit the action of the H+ /K+ ATPase. (irreversible inhibitor) briefly explain how second and third class of compound will work?
You are going to go out with a bunch of friends to a restaurant with the best pizza in town. Your favorite is the pizza covered with cheese, tomato and lots of garlic and onions. The only problem is that you know that later in the evening you will be suffering from heartburn and indigestion. Decades ago, the only choice was to take some antacids after overeating pizza, but today there are multiple choices of preventative medications that act to stop heartburn before it starts.
The stomach is a highly acidic environment that is further acidified after ingestion of food, which triggers a hormone-stimulated cascade. This hormone stimulation results in the activation of a H+ /K+ ATPase channel ("proton pump") that releases additional protons into the stomach cavity. Heartburn occurs when the acid in the stomach undergoes reflux and backs up into the esophagus, giving you that burning feeling in the chest. There are three types of remedies available.
1. Antacids such as calcium carbonate act simply to neutralize stomach acid, thus raising the pH of the stomach juices. This provides temporary relief from heartburn.
2.A second class of compounds, including the drugs Zantac, Pepcid, and Tagamet, act as receptor antagonists of histamine receptors that triggers the release of H+ /K+ ATPase pump by a cascade of reaction. (hint: spicy food – acidity, tomatoes trigger the release of histamine). What happens when you take Zantac what will it do to the pump?
3.The third type, which includes Prilosec and Prevacid, directly inhibit the action of the H+ /K+ ATPase. (irreversible inhibitor)
briefly explain how second and third class of compound will work?
Step by step
Solved in 2 steps
