Answer numbers 1 and 2    1. Which of the following best describes the chemical composition of lipids? a. It is composed mostly of hydrocarbons and soluble in non-polar organic solvents. b. It is either an aldehyde or ketone, and has more than one hydroxyl group. c. It is composed of amino group and carboxylic group bonded to a carbon skeleton. d. It is composed of a nitrogen base linked to a phosphorylated sugar. 2. Enzyme methylmalonyl-CoA mutase converts methylmalonyl-CoA to succinyl-CoA in the presence of vitamin B12. In patients with B12 deficiency, methylmalonic acid (MMA) levels will accumulate, as it cannot be converted to succinyl-CoA. It is hypothesized that elevated levels of MMA, along with elevated levels of homocysteine, contribute to myelin damage, accounting for the neurologic deficits, such as neuropathy and ataxia, seen in these patients. Under conditions of vitamin B12 deficiency, when methylmalonyl-CoA mutase may lack vitamin B12, the enzyme would be referred to as the _. a. apoenzyme b. cofactor c. coenzyme d. holoenzyme e. isoenzymes

Biochemistry
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Chapter1: Biochemistry: An Evolving Science
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Answer numbers 1 and 2 
 
1. Which of the following best describes the chemical composition of lipids?
a. It is composed mostly of hydrocarbons and soluble in non-polar organic solvents.
b. It is either an aldehyde or ketone, and has more than one hydroxyl group.
c. It is composed of amino group and carboxylic group bonded to a carbon skeleton.
d. It is composed of a nitrogen base linked to a phosphorylated sugar.
2. Enzyme methylmalonyl-CoA mutase converts methylmalonyl-CoA to succinyl-CoA in the presence of vitamin B12. In patients with B12 deficiency, methylmalonic acid (MMA) levels will accumulate, as it cannot be converted to succinyl-CoA. It is hypothesized that elevated levels of MMA, along with elevated levels of homocysteine, contribute to myelin damage, accounting for the neurologic deficits, such as neuropathy and ataxia, seen in these patients. Under conditions of vitamin B12 deficiency, when methylmalonyl-CoA mutase may lack vitamin B12, the enzyme would be referred to as the _.
a. apoenzyme
b. cofactor
c. coenzyme
d. holoenzyme
e. isoenzymes
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