, and once an individual is infected with virus x we can always detect the virus in the blood in the future. However, assaying (measuring) the blood for virus X is very expensive. Virus X has only recently been discovered, so no participants in the ALIVE cohort have had Virus X measured yet. Q1. What is the best study design for the research team to use, based on the description above? Cross-sectional Prospective cohort Retrospective cohort Case-control Nested case-control Q2. The most appropriate measure of association for these data is the: Chi-square Mortality rate Odds ratio
A research team reads a journal article about a new finding that countries with greater prevalence of infection with Virus X also had greater prevalence of brain cancer (a rare disease). The research team wants to determine whether there is an association between virus X and brain cancer by using a study design that can provide a greater quality of evidence. They decide to use their access to a large existing prospective cohort study called ALIVE that enrolled participants at birth and followed them until death. At ALIVE study entry (baseline), participants answered a survey and the study team collected blood specimens that were stored long-term in the freezer. Assume that virus x is not curable, and once an individual is infected with virus x we can always detect the virus in the blood in the future. However, assaying (measuring) the blood for virus X is very expensive. Virus X has only recently been discovered, so no participants in the ALIVE cohort have had Virus X measured yet.
Q1. What is the best study design for the research team to use, based on the description above?
Cross-sectional
Prospective cohort
Retrospective cohort
Case-control
Nested case-control
Q2. The most appropriate measure of association for these data is the:
Chi-square
Mortality rate
Odds ratio
Relative risk or risk ratio
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