An intermediate of the citric acid cycle that undergoes reductive amination with glutamine as nitrogen donor is a) a-ketoglutarate b) Glutamine c) NADPH d) H+
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- two of the reduced electron carriers in the citric acid cycle come directly from a) isomerization of citrate b) lactic acid fermentation under anaerobic conditions c) condensation of acetate to form long-chain fatty acid d) oxidative decarboxylations e) succinate dehydrogenase reactionwhich of the following glycolytic reactions is an oxidation? a) G3P to 1,3-BPG b) PEP to Pyr c) lactic acid fermentation under anaerobic conditions d) condensation of acetate with OAA e) succinate decarboxylase reactionWhich of the following citric acid cycle enzymes catalyzes substrate-level phosphorylation? A) isocitrate dehydrogenase B) α-ketoglutarate dehydrogenase C) succinyl CoA synthetase D) succinate dehydrogenase E) malate dehydrogenase
- Citric acid cycle is also considered to be an anabolic pathway, because: a) Some of the reactions in citric acid cycle are reversible b) Some of the intermediates in citric acid cycle can be converted to amino acids c) Bothaandb d) Neither a nor bIn the complete b-oxidation of stearic acid (18:0), a) how many moles of acetyl CoA are produced? b) how many times would the fatty acid pass through the fatty acid spiral for complete oxidation? c) what is the total ATP produced in the citric acid cycle? d) how many moles of NADH are produced? e) how many moles of FADH2 are produced? f) how many moles of ATP are produced after all NADH are reoxidized in the respiratory chain? g) how many moles of ATP are produced after all FADH2 are reoxidized in the respiratory chain? h) how many moles of ATP are produced from the complete oxidation of stearic acid?Phosphofructokinase catalyzes the conversion of ... A) oxaloacetate to citrate OB) glucose to fructose 6-phosphate C) fructose 6-phosphate to fructose 1,6-bisphosphate D) pyruvate to acetyl CoA E) a phosphorylated 6-carbon sugar to two 3-carbon sugars
- What is the likely substrate of α ketoglutatrate dehydrogenase? A) water B) alpha ketoglutatrate C) protons D) ketoacidsDetermine whether the following statements are true or false:- a) The pentose phosphate pathway of glucose conversion is a supplier of NADPH (H +) for reductive syntheses. b) An overdose of insulin causes hypoglycemia in a patient with diabetes mellitus. c) Fructose-6-phosphate is an allosteric regulator of glycolysis.Under anaerobic conditions, Escherichia coli synthesizes an NADH-dependent fumarate reductase rather than succinatedehydrogenase, the flavoprotein that oxidizes succinate to fumarate. a) Write an equation for the reaction catalyzed by fumarate reductase.b) NADH produced by the glyceraldehyde-3-phosphate dehydrogenase reaction is re-oxidized by reducing an organicintermediate. Rather than reduce pyruvate to lactate, anaerobic E. coli utilize fumarate reductase. However, underanaerobiosis, the activity of -ketoglutarate dehydrogenase is virtually nonexistent. Show how fumarate is formed, usinga reaction beginning with PEP and including the necessary TCA cycle enzymes.c) What is the metabolic advantage to anaerobic E. coli in using the fumarate reductase pathway rather than lactatedehydrogenase to re-oxidize NADH?
- E3 of the pyruvate dehydrogenase complex performs which main function? A) removing a proton from TPP forming a carbanion b) catalyzing the condensation of the TPP carbanion with pyruvate to form hydroxyethyl-TPP c) oxidation and transfer of the hydroxyethyl group to lipoic acid d) reoxidation of lipoic acid in order to keep the reaction going Once acetyl-CoA is formed, it usually takes one of two paths. The first is further oxidation in the citric acid cycle. The second is: a) conversion to oxaloacetate which generates glucose by gluconeogenesis b) synthesis of galactose c) activates transcription factors which signal the synthesis of peptidase enzymes d) it is used in the synthesis of fatty acids.Each of the following citric acid cycle enzymes catalyzes electron transfer to NADH/FADH2 except A) isocitrate dehydrogenase. B) α-ketoglutarate dehydrogenase. C) succinyl CoA synthetase. D) succinate dehydrogenase. E) malate dehydrogenase.Using the glycerol-3-phosphate shuttle, determine how many ATP can be produced from one mole of each of the following compounds on complete oxidation?a.) Mannoseb.) Dihydroxyacetone phosphatec.) Citrated.) Malatee.) Succinate