An experiment was done : Synthesis of a potential enzyme inhibitor The product achieved from the experiment was 4.0g. Using the picture provided determine the percentage yield.
An experiment was done : Synthesis of a potential enzyme inhibitor The product achieved from the experiment was 4.0g. Using the picture provided determine the percentage yield.
Chemistry
10th Edition
ISBN:9781305957404
Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Chapter1: Chemical Foundations
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Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...
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An experiment was done : Synthesis of a potential enzyme inhibitor
The product achieved from the experiment was 4.0g. Using the picture provided determine the percentage yield.
Transcribed Image Text:Add 3g of 4-hydroxyacetophenone to 70ml anhydrous dichloromethane in a 250cm³ round
bottom flask. Then add 5ml of triethylamine and stir the mixture for a 1 minute. Cool the
mixture to 0°C in an ice bath and add 3ml of methane sulfonyl chloride whilst stirring the solution
by hand using a glass rod. Add 2-4 anti-bumping granules. Using a heating mantle, reflux the
reaction mixture for 45 minutes. After cooling to room temperature, carefully pour the reaction
mixture into a beaker containing approximately 100cm³ of ice. After the ice has melted, wash
the dichloromethane layer twice with water (50ml each time). Wash the dichloromethane twice
with saturated sodium bicarbonate (NaHCO3) solution (50ml each time) and finally once with
water (80ml). Dry the dichloromethane layer over anhydrous magnesium sulfate. After filtering
off the solid magnesium sulfate, remove the dichloromethane using a rotary evaporator. You
should avoid smelling the product as there may still be some residue of methane sulfonyl
chloride present in the round bottom flask. Record the weight and therefore determine the
percentage yield.
15
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