An efficacy study was conducted for the drug pamidronate in patients with stage III multiple myeloma and at leastone lytic lesion. In this randomized clinical trial, patients were assigned at random to receive either pamidronate orplacebo. One endpoint reported was the occurrence of any skeletal events after 9 cycles of treatment or non-occurrence.TreatmentGroupPamidronatePlaceboOccurrence of Skeletal EventYes4774121No149107256196181377What percent of patients received pamidronate? What percent of patients experienced the occurrence of anyskeletal events? Calculate the odds ratio of the occurrence of any skeletal events between the pamidronate group and the placebogroup. Calculate the relative risk of the occurrence of any skeletal events between the pamidronate group and theplacebo group.

Odd ratio measure the odd's of disease exposed to the case and control. It is calculated using the…

Answered: An efficacy study was conducted for the…

MATLAB: An Introduction with Applications

6th Edition

ISBN:9781119256830

Author:Amos Gilat

Publisher:Amos Gilat

Chapter1: Starting With Matlab

Section: Chapter Questions

Problem 1P

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In the past 10 years, the prevalence of peanut allergies has doubled in Western countries. Is consumption or avoidance of peanuts in infants related to the development of peanut allergies in infants at risk? Subjects included infants between four and 11 months with severe eczema, egg allergy, or both but who did not display a preexisting sensitivity to peanuts based on a skin-prick test. The infants were randomly assigned to either a treatment that avoided consuming peanut protein or a treatment in which at least 6 grams of peanut protein were consumed per week. The response was the presence or absence of peanut allergy at 60 months of age. In the avoidance group containing 263 infants, 36 had developed a peanut allergy at 60 months of age, while in the consumption group containing 266 infants, five had developed a peanut allergy. George Du Toit et al., "Randomized trial of peanut consumption in infants at risk for peanut allergy," New England Journal of Medicine, 372 (2015), pp.…
A clinical trial is conducted to compare an experimental medication to placebo to reduce the symptoms of asthma. Two hundred participants are enrolled in the study and randomized to receive either the experimental medication or placebo. The primary outcome is self-reported reduction of symptoms. Among 100 participants who receive the experimental medication, 38 report a reduction of symptoms as compared to 21 participants of 100 assigned to placebo. When you test if there is a significant difference in the proportions of participants reporting a reduction of symptoms between the experimental and placebo groups. Use α = 0.05. What should the researcher’s conclusion be for a 5% significance level? Reject H0because 2.64 ≥ 1.960. We have statistically significant evidence at α = 0.05 to show that there is a difference in the proportions of patients reporting a reduction in symptoms. We reject H0 at the 5% level because 2.64 is greater than 1.96. We do have statistically…
A pharmaceutical company has developed a new drug called Antisubcillin to treat substance use disorder. They have just completed an experiment assessing the safety of the drug. To test safety, 100 rats were given 20 mg of Antisubcillin and 100 rats were given a placebo. The study was conducted as a double-blind controlled study and so the researchers did not know which rats were receiving the drug and which were receiving the placebo. The number of negative side effects displayed by each rat over the course of 8 weeks was recorded. Which statistical test should be used to analyze these data? z test one-sample t test independent samples t test dependent samples t test
NCI Cancer Bulletin, December 2, 2008 Volume 5 / Number 24 Title of the article: After Menopause, Weight Affects Breast Cancer Rates More than Mammography Use Women who are overweight or obese after menopause face an increased risk of breast cancer, but a large prospective cohort study indicates that the frequency of mammography use and screening accuracy are not the primary explanations for higher rates of breast cancer in these women. The same is true of large, invasive breast cancer tumors and advanced stage disease; risk increases with weight, but higher rates are not explained by the frequency or accuracy of screening mammography before breast cancer was diagnosed. The study appears in the December 3 Journal of the National Cancer Institute. Dr. Karla Kerlikowske of the San Francisco Veterans Affairs Medical Center and colleagues gathered data on 287,115 postmenopausal women who were registered in the Breast Cancer Surveillance Consortium database. Reflecting a trend in the…
A clinical trial is conducted to compare an experimental medication to placebo to reduce the symptoms of asthma. Two hundred participants are enrolled in the study and randomized to receive either the experimental medication or placebo. The primary outcome is self-reported reduction of symptoms. Among 100 participants who receive the experimental medication, 38 report a reduction of symptoms as compared to 21 participants of 100 assigned to placebo. When you test if there is a significant difference in the proportions of participants reporting a reduction of symptoms between the experimental and placebo groups. Use α = 0.05. What should the researcher’s conclusion be for a 5% significance level? Reject H0because 2.64 ≥ 1.960. We have statistically significant evidence at α = 0.05 to show that there is a difference in the proportions of patients reporting a reduction in symptoms. We reject H0 at the 5% level because 2.64 is greater than 1.96. We do have statistically…
Here is the scenario for your Between Subjects Independent One Way ANOVA: Dr. Xena is interested in determine which type of therapy best helps persons with bipolar depression. She gathers a random and representative sample of men and women ages 18-95 years of age who have a diagnosis of Bipolar Depression who are taking Lithium for at least 6 months. She randomly assigns participants to conditions and measures well being scores after 4 months of therapy. Well being scores range from 0-100, with 100 being high well-being (feel good and experiencing no mood swings). Here is the data: Cognitive Therapy EMDR Therapy Psychoanalytical Therapy 15 72 28 78 91…
A clinical trial is conducted to compare an experimental medication to placebo to reduce the symptoms of asthma. Two hundred participants are enrolled in the study and randomized to receive either the experimental medication or placebo. The primary outcome is self-reported reduction of symptoms. Among 100 participants who receive the experimental medication, 38 report a reduction of symptoms as compared to 21 participants of 100 assigned to placebo. When you test if there is a significant difference in the proportions of participants reporting a reduction of symptoms between the experimental and placebo groups. Use α = 0.05. What should the researcher’s conclusion be for a 5% significance level? Reject H0because 2.64 ≥ 1.960. We have statistically significant evidence at α = 0.05 to show that there is a difference in the proportions of patients reporting a reduction in symptoms. We reject H0 at the 5% level because 2.64 is greater than 1.96. We do have statistically…
A study investigated the joint effects of sleep quality and sleep duration on the development of coronary heart disease (CHD). A total of 60,586 individuals aged 40 and older with no current or prior history of CHD were enrolled into the study. A self-administered questionnaire was used to collect information on sleep quality and duration at the start of the study, and 43,910 participants reported getting ³6 hours of sleep per day. Participants were followed for approximately 12 years, for a total of 152,000 person-years among those getting <6 hours sleep/day and 527,000 person-years among those getting ³6 hours sleep/day. Out of 2,740 participants who developed CHD throughout follow-up, 721 participants reported getting <6 hours of sleep per day at baseline. Question 10: What is the incidence rate of coronary heart disease among all participants in the study?
A study in a journal published by the American Academy of Pediatrics (as reported in the Miami Herald, Jan. 14, 1997) seems to suggest that preschoolers who drink more than 12 ounces of fruit juice a day tend to be heavier and shorter than preschoolers who do not. The study involved a random sample of 168 healthy youngsters of whom 59 drank on average more than 12 ounces of fruit juice per day. Each child was weighed and measured. The measurements were then converted to percentage of normal height and weight for a child of that age and gender. For example, a weight percentage of 1.1 indicates that the child is 10% heavier than average. A recorded 0.80 indicates the child is 20% below the average. An average weight is recorded as 1.0. Same with height. Column 1: Juice 1- indicates child DID drink > 12 oz 2- child DID NOT drink > 12 oz Column 2: Weight% weight converted to percent of…
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In the Utah study, among participants who reported contact with a family member with known SARS-COV-2 infection, 14.4 % were seropositive. In your area, you are noticing a similar trend. Based on your study with your team, you have determined that among the 100 people in your sample who reported contact with a family member with known SARS-CoV-2 infection, 20% of the individuals were seropositive. Answer the following questions about your study: (a) What is the n? (b) What is the p (use two places after the decimal)? (c) What is the q (use two places after the decimal)? (d) What is the expected value for 100 seropostive cases? (e) What is the variance for 100 seropositive cases?

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