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Aminotransferases (transaminases) amino acid during transamination

Aminotransferases (transaminases) amino acid during transamination

Biochemistry
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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sapling learning (a) Identify the group in pyridoxal phosphate (PLP) that covalently binds enzyme and substrate. Hint A B _H OH Previous CH3 (b) Aminotransferases (transaminases) must deaminate one amino acid and add an amino group to another amino acid during transamination. How do the two processes differ? Map The second part of the reaction (adding an amino group) is the reverse of the first (deamination). The second part of the reaction takes place at a separate amino acid residue in the active site. The first reaction involves the formation of a Schiff base, whereas the second does not. The coenzyme PLP must be activated by an external amino group before it can catalyze the removal of the amino group from the first amino acid. Give Up & View Solution Check Answer Next Exit
Transcribed Image Text:sapling learning (a) Identify the group in pyridoxal phosphate (PLP) that covalently binds enzyme and substrate. Hint A B _H OH Previous CH3 (b) Aminotransferases (transaminases) must deaminate one amino acid and add an amino group to another amino acid during transamination. How do the two processes differ? Map The second part of the reaction (adding an amino group) is the reverse of the first (deamination). The second part of the reaction takes place at a separate amino acid residue in the active site. The first reaction involves the formation of a Schiff base, whereas the second does not. The coenzyme PLP must be activated by an external amino group before it can catalyze the removal of the amino group from the first amino acid. Give Up & View Solution Check Answer Next Exit
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