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Although insulin initially acts through a tyrosine kinase receptor it also subsequently results in activation of a Ser/Thr protein kinase. Which one? A) Protein kinase A B) Protein kinase B C) Protein kinase C D) Ras E) Phosphoinositide-3-kinase

Although insulin initially acts through a tyrosine kinase receptor it also subsequently results in activation of a Ser/Thr protein kinase. Which one? A) Protein kinase A B) Protein kinase B C) Protein kinase C D) Ras E) Phosphoinositide-3-kinase

Biochemistry
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
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Although insulin initially acts through a tyrosine kinase receptor it also subsequently results in activation of a Ser/Thr protein kinase. Which one? A) Protein kinase A B) Protein kinase B C) Protein kinase C D) Ras E) Phosphoinositide-3-kinase
Transcribed Image Text:Although insulin initially acts through a tyrosine kinase receptor it also subsequently results in activation of a Ser/Thr protein kinase. Which one? A) Protein kinase A B) Protein kinase B C) Protein kinase C D) Ras E) Phosphoinositide-3-kinase
Expert Solution
Introduction

Receptor tyrosine kinase (RTKs) :- 2nd major type of cell surface receptors.

Ligand may be:- insulin, EGF, FGF, PDGF, etc.

Physiologic functions :- promote growth, proliferation, development, maintainance, etc. 

3 major pathway of RTK:- 

1. RAS- MAP KINASE 

2. IP3- DAG PATHWAY 

3. PI-3 KINASE PATHWAY

 

 

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