FIGURE 16-18 TA100, TA1538, and TA1535 are strains of Salmonella bearing different histidine auxotrophic mutations. The TA100 strain is highly sensitive to reversion through base-pair substitution. The TA1535 and TA1538 strains are sensitive to reversion through frameshift mutation. The test results show that S-- His+ rersion test aflatoxin B, is a potent mutation that causes base-pair substitutions but not frameshifts. [Data from J. McCann and B. N. Ames, in W. G. Flamm and M. A. Mehlman, eds. Advances in Modern Technology, vol. 5. Copyright by Hemisphere Publishing Corporation, Washington, D.C.] Ames test of aflatoxin B, mutagenicity 2000 TA100 1500 1000 OCH3 500 Aflatoxin B, TA1538 TA1535 20 40 60 80 100 120 140 Aflatoxin B, dose (ng) Revertant colonies per plate O: Aflatoxin B, forms a bulky addition product Guanine Aflatoxin B, HO HN OCH3 H2N DNA backbone mutagenicity of comp However, it became rather, some carcino mutagenic agents. Ty- enzymatic reactions FIGURE 16-16 Metabolically activated aflatoxin B, binds to DNA.
FIGURE 16-18 TA100, TA1538, and TA1535 are strains of Salmonella bearing different histidine auxotrophic mutations. The TA100 strain is highly sensitive to reversion through base-pair substitution. The TA1535 and TA1538 strains are sensitive to reversion through frameshift mutation. The test results show that S-- His+ rersion test aflatoxin B, is a potent mutation that causes base-pair substitutions but not frameshifts. [Data from J. McCann and B. N. Ames, in W. G. Flamm and M. A. Mehlman, eds. Advances in Modern Technology, vol. 5. Copyright by Hemisphere Publishing Corporation, Washington, D.C.] Ames test of aflatoxin B, mutagenicity 2000 TA100 1500 1000 OCH3 500 Aflatoxin B, TA1538 TA1535 20 40 60 80 100 120 140 Aflatoxin B, dose (ng) Revertant colonies per plate O: Aflatoxin B, forms a bulky addition product Guanine Aflatoxin B, HO HN OCH3 H2N DNA backbone mutagenicity of comp However, it became rather, some carcino mutagenic agents. Ty- enzymatic reactions FIGURE 16-16 Metabolically activated aflatoxin B, binds to DNA.
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
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Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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Question
Based on the mode of action of aflatoxin (Figure 16-16),
propose a scenario that explains its response in the Ames
test (Figure 16-18)
![FIGURE 16-18 TA100, TA1538, and
TA1535 are strains of Salmonella bearing
different histidine auxotrophic mutations.
The TA100 strain is highly sensitive to
reversion through base-pair substitution.
The TA1535 and TA1538 strains are
sensitive to reversion through frameshift
mutation. The test results show that
S-- His+
rersion test
aflatoxin B, is a potent mutation that
causes base-pair substitutions but not
frameshifts. [Data from J. McCann and B. N.
Ames, in W. G. Flamm and M. A. Mehlman,
eds. Advances in Modern Technology, vol. 5.
Copyright by Hemisphere Publishing
Corporation, Washington, D.C.]
Ames test of aflatoxin B, mutagenicity
2000
TA100
1500
1000
OCH3
500
Aflatoxin B,
TA1538
TA1535
20
40 60
80 100 120
140
Aflatoxin B, dose (ng)
Revertant colonies per plate
O:](/v2/_next/image?url=https%3A%2F%2Fcontent.bartleby.com%2Fqna-images%2Fquestion%2Faba0e6c5-f5ad-458a-8622-6745a6b65fc5%2F26de6403-5f70-4973-a95f-c9a0e904c127%2Fz5l4it_processed.png&w=3840&q=75)
Transcribed Image Text:FIGURE 16-18 TA100, TA1538, and
TA1535 are strains of Salmonella bearing
different histidine auxotrophic mutations.
The TA100 strain is highly sensitive to
reversion through base-pair substitution.
The TA1535 and TA1538 strains are
sensitive to reversion through frameshift
mutation. The test results show that
S-- His+
rersion test
aflatoxin B, is a potent mutation that
causes base-pair substitutions but not
frameshifts. [Data from J. McCann and B. N.
Ames, in W. G. Flamm and M. A. Mehlman,
eds. Advances in Modern Technology, vol. 5.
Copyright by Hemisphere Publishing
Corporation, Washington, D.C.]
Ames test of aflatoxin B, mutagenicity
2000
TA100
1500
1000
OCH3
500
Aflatoxin B,
TA1538
TA1535
20
40 60
80 100 120
140
Aflatoxin B, dose (ng)
Revertant colonies per plate
O:
Transcribed Image Text:Aflatoxin B, forms a bulky addition product
Guanine
Aflatoxin B,
HO
HN
OCH3
H2N
DNA
backbone
mutagenicity of comp
However, it became
rather, some carcino
mutagenic agents. Ty-
enzymatic reactions
FIGURE 16-16 Metabolically activated
aflatoxin B, binds to DNA.
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