Addition of oxygen nucleophiles: ROH add'n w/acid cat.; prep. of stable acetals 18.13) ● ● aldehydes/ketones react w/ROH to form unstable/unisolable hemiacetals aldehydes/ketones react w/2 equiv. of ROH and acid catalyst to afford stable/isolable acetals, with a hemiacetal as a mechanistic intermediate Sample rxn: Propose the mechanism: + 2 CH3 H H* (cat.) X OCH3 + (chap. 17 & 18) Note: acetal carbon has same oxid. state as C=O carbon OCH3 H an acetal (NOT an ether or "diether")

Addition of oxygen nucleophiles: ROH add'n w/acid cat.; prep. of stable acetals 18.13) ● ● aldehydes/ketones react w/ROH to form unstable/unisolable hemiacetals aldehydes/ketones react w/2 equiv. of ROH and acid catalyst to afford stable/isolable acetals, with a hemiacetal as a mechanistic intermediate Sample rxn: Propose the mechanism: + 2 CH3 H H* (cat.) X OCH3 + (chap. 17 & 18) Note: acetal carbon has same oxid. state as C=O carbon OCH3 H an acetal (NOT an ether or "diether")

Chemistry

10th Edition

ISBN:9781305957404

Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Chapter1: Chemical Foundations

Section: Chapter Questions

Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...

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