Acyl-CoA synthase is the enzyme that activates a fatty acid by converting it to a fatty acyl-CoA in a series of two reactions. In the first reaction, the fatty acid reacts with ATP and one of the products formed is ADP. The other product reacts in a second reaction with CoASH to form the fatty acyl-CoA. Propose a mechanism for each of the reactions.
Organic Chemistry of Metabolic Pathways
Metabolic pathways allude to the arrangement of chemical catalyzed reactions that lead to the transformation of a substance into the final product. Metabolic pathways incorporate a progression of reaction where the substrate is changed continuously and the transitional metabolites are persistently recovered.
Glucogenesis
Glucogenesis is a metabolic pathway in which glucose is produced from carbon substrates that are not carbohydrates. This process is observed in plants, animals, fungi, bacteria and other micro organisms. The general definition for glucogenesis or gluconeogenesis is as follows,
Acyl-CoA synthase is the enzyme that activates a fatty acid by converting it to a fatty acyl-CoA in a series of two reactions. In the first reaction, the fatty acid reacts with ATP and one of the products formed is ADP. The other product reacts in a second reaction with CoASH to form the fatty acyl-CoA. Propose a mechanism for each of the reactions.
Glycolysis:
It is pathway which describes conversion of one molecule of glucose into two molecules of pyruvate. The series involves 10 reactions.
NAD+Molecule:
It is the oxidized form of Nicotinamide adenine dinucleotide (NAD) which exists in all cells and needed for activation of enzymes.
NADH molecule :
It is coenzyme which gets oxidized on reducing another compound. The oxidized form of NADH is MAD+.
Fatty acid conversion to fatty acyl — CoA:
Many steps are involved in the catabolism of fats in our body. A fatty acid formed can be converted into fatty acyl-CoA in the presence of an enzyme called Acyl-CoA synthase. The fatty acid should be activated before it can be metabolized.
Step by step
Solved in 2 steps with 1 images
