Acetyi CoA Oxaloneetate CoA NADH Citrate NAD Isocitrate Malate Faniarate NAD NADH FADH; FAD a- Ketoghutarate Succinate co, NAD ATP Succinyt CuA4 NADH ADP - P, If you were told to add one of the eight citric acid cycle intermediates to the culture medium fo yeast growing in the laboratory, what do you think would happen to the rates of ATP and carbon dioxide production? (see the above figure) a. There would be no change in ATP production, but the rate of CO2 production would increase. b. The rates of ATP production and CO2 production would both increase, c. The rate of ATP production would increase, but the rate of CO2 production would decrease. d. The rates fo ATP and CO2 production would both decrease.

Biochemistry
6th Edition
ISBN:9781305577206
Author:Reginald H. Garrett, Charles M. Grisham
Publisher:Reginald H. Garrett, Charles M. Grisham
Chapter27: Metabolic Integration And Organ Specialization
Section: Chapter Questions
Problem 9P
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### Citric Acid Cycle Diagram Explanation

The diagram above represents the Citric Acid Cycle (also known as the Krebs Cycle), a crucial metabolic pathway that occurs in the mitochondria of cells. It is fundamental in the conversion of carbohydrates, fats, and proteins into carbon dioxide, water, and energy, primarily in the form of ATP.

- **Key Components**: 
  - **Acetyl CoA**: This molecule enters the cycle, combining with Oxaloacetate to form Citrate.
  - **Citrate**: Transformed through a series of steps to produce energy carriers and CO₂.
  - **Isocitrate, α-Ketoglutarate, Succinyl CoA, Succinate, Fumarate, Malate, and Oxaloacetate**: Intermediates in the cycle, each undergoing specific conversions.

- **Energy Transfer:** 
  - NAD⁺ is reduced to NADH.
  - FAD is reduced to FADH₂.
  - GDP is converted to GTP, which can be converted to ATP.
  - ADP is phosphorylated to ATP.

- **Carbon Dioxide Production**: CO₂ is released during the conversion of Isocitrate to α-Ketoglutarate and from α-Ketoglutarate to Succinyl CoA.

### Question

If a component of the citric acid cycle is added to a yeast culture, how will ATP and CO₂ production be affected?

#### Options

a. No change in ATP production, but CO₂ production increases.

b. Both ATP and CO₂ production rates increase.

c. ATP production increases, but CO₂ production decreases.

d. Both ATP and CO₂ production rates decrease.

### Evaluation

The addition of intermediates could replenish cycle components, potentially increasing throughput and enhancing both ATP and CO₂ production. Consider the implications of the specific intermediate added and its role in the cycle.
Transcribed Image Text:### Citric Acid Cycle Diagram Explanation The diagram above represents the Citric Acid Cycle (also known as the Krebs Cycle), a crucial metabolic pathway that occurs in the mitochondria of cells. It is fundamental in the conversion of carbohydrates, fats, and proteins into carbon dioxide, water, and energy, primarily in the form of ATP. - **Key Components**: - **Acetyl CoA**: This molecule enters the cycle, combining with Oxaloacetate to form Citrate. - **Citrate**: Transformed through a series of steps to produce energy carriers and CO₂. - **Isocitrate, α-Ketoglutarate, Succinyl CoA, Succinate, Fumarate, Malate, and Oxaloacetate**: Intermediates in the cycle, each undergoing specific conversions. - **Energy Transfer:** - NAD⁺ is reduced to NADH. - FAD is reduced to FADH₂. - GDP is converted to GTP, which can be converted to ATP. - ADP is phosphorylated to ATP. - **Carbon Dioxide Production**: CO₂ is released during the conversion of Isocitrate to α-Ketoglutarate and from α-Ketoglutarate to Succinyl CoA. ### Question If a component of the citric acid cycle is added to a yeast culture, how will ATP and CO₂ production be affected? #### Options a. No change in ATP production, but CO₂ production increases. b. Both ATP and CO₂ production rates increase. c. ATP production increases, but CO₂ production decreases. d. Both ATP and CO₂ production rates decrease. ### Evaluation The addition of intermediates could replenish cycle components, potentially increasing throughput and enhancing both ATP and CO₂ production. Consider the implications of the specific intermediate added and its role in the cycle.
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