(a)Calculate theoretical yield of both williamson ether synthesis of phenacetine and amide synthesis of phenacetin. (b) calculate the percent yield of phenacetin obtained via williamson ether synthesis. (c) Calculate the percent yeild of phenacetin obtained via the amide synthesis.
(a)Calculate theoretical yield of both williamson ether synthesis of phenacetine and amide synthesis of phenacetin. (b) calculate the percent yield of phenacetin obtained via williamson ether synthesis. (c) Calculate the percent yeild of phenacetin obtained via the amide synthesis.
Chemistry
10th Edition
ISBN:9781305957404
Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Chapter1: Chemical Foundations
Section: Chapter Questions
Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...
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Data:
Density of p-phenetidine is 1.065g/mol
Mass of filter paper: 0.680 g
Mass of filter paper and product: 1.482 g
Melting Point: 134-136oC
Amide Synthesis:
Mass of filter paper: 0.686 g
Mass of filter paper and product: 1.589 g
Melting Point: 135-137oC
Mixed Melting Point (product of amide synthesis mixed with Williamson Ether synthesis product): 134-136oC
(a)Calculate theoretical yield of both williamson ether synthesis of phenacetine and amide synthesis of phenacetin.
(b) calculate the percent yield of phenacetin obtained via williamson ether synthesis.
(c) Calculate the percent yeild of phenacetin obtained via the amide synthesis.
Transcribed Image Text:b Js Reagents and Properties
bp
C)
molar mass
mp
C)
substance
quantity
(g/mol)
oi acetic anhydride
102.09
138-140
1.2 mL
activated carbon
deutero-chloroform"
0.4 g
1 mL
6 mL
120
61
ethanol, 95%
hydrochloric acid,
concentrated
1.0 mL
phenacetin'
p-phenetidine
potassium bromide
sodium acetate
179
134-136
1.38 g
100 mg
137.18
4
250
2.0 g
82.03
* for NMR
product
for IR
Transcribed Image Text:Reagents and Properties
bp
C)
molar mass
mp
(C)
substance
quantity
g/mol)
1,51g
1.64 g
1 mL
169-172
151.17
108.97
120
46.07
p-acetamidophenol
bromoethane
deutero-chloroform
ethanol, 100%
ethanol, 95%
phenacetin'
potassium bromide
25% sodium methoxide
in methanol
37--40
61
4 mL
78
6 mL
179
134-136
100 mg
2.5 mL
for NMR
product
for IR
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