After the solid has dissolved (it may dissolve, precipitate, and redissolve), heat the mixture for an additional 10 minutes at about 100°C to complete the reaction. (Final product crude Acetaminophen) <--What if the following was heated to 200 °C instead?
Heat the reaction mixture, (p-aminophenol, distilled H2O, and acetic anhydride). with stirring, directly on a hot plate, using a thermometer to monitor the internal temperature (about 100°C). After the solid has dissolved (it may dissolve, precipitate, and redissolve), heat the mixture for an additional 10 minutes at about 100°C to complete the reaction. (Final product crude Acetaminophen) <--What if the following was heated to 200 °C instead?
When p-aminophenol reacts with acetic anhydride at lower temperature 100°C then reaction occurs through more nucleophilic NH2 group and results K.C.P. paracetamol.
But at an elevated temperature 200°C reaction occurs with OH group and gives O-acetyl p-aminophenol which is TCP.
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